Biology:UDP-N-acetylgalactosamine-4-sulfate sulfotransferase
UDP-N-acetylgalactosamine-4-sulfate sulfotransferase | |||||||||
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Identifiers | |||||||||
EC number | 2.8.2.7 | ||||||||
CAS number | 37278-32-3 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, an UDP-N-acetylgalactosamine-4-sulfate sulfotransferase (EC 2.8.2.7) is an enzyme that catalyzes the chemical reaction
- 3'-phosphoadenylyl sulfate + UDP-N-acetyl-D-galactosamine 4-sulfate [math]\displaystyle{ \rightleftharpoons }[/math] adenosine 3',5'-bisphosphate + UDP-N-acetyl-D-galactosamine 4,6-bissulfate
Thus, the two substrates of this enzyme are 3'-phosphoadenylyl sulfate and UDP-N-acetyl-D-galactosamine 4-sulfate, whereas its two products are adenosine 3',5'-bisphosphate and UDP-N-acetyl-D-galactosamine 4,6-bissulfate.
This enzyme belongs to the family of transferases, specifically the sulfotransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is 3'-phosphoadenylyl-sulfate:UDP-N-acetyl-D-galactosamine-4-sulfate 6-sulfotransferase. Other names in common use include uridine diphosphoacetylgalactosamine 4-sulfate sulfotransferase, uridine diphospho-N-acetylgalactosamine 4-sulfate sulfotransferase, and uridine diphosphoacetylgalactosamine 4-sulfate sulfotransferase.
References
- "Enzymatic transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate to uridine diphosphate N-acetylgalactosamine 4-sulfate". J. Biol. Chem. 242 (9): 2288–90. 1967. PMID 6022874.
![]() | Original source: https://en.wikipedia.org/wiki/UDP-N-acetylgalactosamine-4-sulfate sulfotransferase.
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