Biology:UDP-N-acetylglucosamine 4,6-dehydratase (configuration-retaining)

From HandWiki
Short description: Class of enzymes
UDP-N-acetylglucosamine 4,6-dehydratase (configuration-retaining)
Identifiers
EC number4.2.1.135
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

UDP-N-acetylglucosamine 4,6-dehydratase (configuration-retaining) (EC 4.2.1.135, PglF) is an enzyme with systematic name UDP-N-acetyl-α-Dglucosamine hydro-lyase (configuration-retaining; UDP-2-acetamido-2,6-dideoxy-α-Dxylo-hex-4-ulose-forming).[1][2] This enzyme catalyses the following chemical reaction

UDP-N-acetyl-α-D-glucosamine [math]\displaystyle{ \rightleftharpoons }[/math] UDP-2-acetamido-2,6-dideoxy-α-D-xylo-hex-4-ulose + H2O

This enzyme contains NAD+ as a cofactor.

References

  1. "Functional characterization of dehydratase/aminotransferase pairs from Helicobacter and Campylobacter: enzymes distinguishing the pseudaminic acid and bacillosamine biosynthetic pathways". The Journal of Biological Chemistry 281 (2): 723–32. January 2006. doi:10.1074/jbc.m511021200. PMID 16286454. 
  2. "In vitro biosynthesis of UDP-N,N'-diacetylbacillosamine by enzymes of the Campylobacter jejuni general protein glycosylation system". Biochemistry 45 (45): 13659–69. November 2006. doi:10.1021/bi061456h. PMID 17087520. 

External links