Biology:Very-long-chain enoyl-CoA reductase

From HandWiki
Short description: Class of enzymes
Very-long-chain enoyl-CoA reductase
Identifiers
EC number1.3.1.93
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Very-long-chain enoyl-CoA reductase (EC 1.3.1.93, TSC13 (gene name), CER10 (gene)) is an enzyme with systematic name very-long-chain acyl-CoA:NADP+ oxidoreductase.[1][2][3][4] This enzyme catalyses the following chemical reaction

a very-long-chain acyl-CoA + NADP+ ⇌ a very-long-chain trans-2,3-dehydroacyl-CoA + NADPH + H+

This is the fourth component of the elongase, a microsomal protein complex responsible for extending palmitoyl-CoA and stearoyl-CoA.

References

  1. ↑ "Tsc13p is required for fatty acid elongation and localizes to a novel structure at the nuclear-vacuolar interface in Saccharomyces cerevisiae". Molecular and Cellular Biology 21 (1): 109–25. January 2001. doi:10.1128/MCB.21.1.109-125.2001. PMID 11113186. 
  2. ↑ "Functional characterization of the Arabidopsis thaliana orthologue of Tsc13p, the enoyl reductase of the yeast microsomal fatty acid elongating system". Journal of Experimental Botany 55 (396): 543–5. February 2004. doi:10.1093/jxb/erh061. PMID 14673020. 
  3. ↑ "Targeting of Tsc13p to nucleus-vacuole junctions: a role for very-long-chain fatty acids in the biogenesis of microautophagic vesicles". Molecular Biology of the Cell 16 (9): 3987–98. September 2005. doi:10.1091/mbc.E05-04-0290. PMID 15958487. 
  4. ↑ "Disruptions of the Arabidopsis Enoyl-CoA reductase gene reveal an essential role for very-long-chain fatty acid synthesis in cell expansion during plant morphogenesis". The Plant Cell 17 (5): 1467–81. May 2005. doi:10.1105/tpc.104.030155. PMID 15829606. 



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