Biology:Xaa-Pro dipeptidyl-peptidase
From HandWiki
| Xaa-Pro dipeptidyl-peptidase | |||||||||
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| Identifiers | |||||||||
| EC number | 3.4.14.11 | ||||||||
| CAS number | 54249-88-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Xaa-Pro dipeptidyl-peptidase (EC 3.4.14.11, X-prolyl dipeptidyl aminopeptidase, PepX, X-prolyl dipeptidyl peptidase is an enzyme.[1][2][3][4][5] It catalyses the following chemical reaction
- Hydrolyses Xaa-Pro bonds to release unblocked, N-terminal dipeptides from substrates including Ala-Pro-p-nitroanilide and (sequentially) Tyr-Pro--Phe-Pro--Gly-Pro--Ile
The intracellular enzyme from Lactococcus lactis (190-kDa) is the type example of peptidase family S15.
References
- ↑ "Intracellular X-prolyl dipeptidyl peptidase from Lactococcus lactis spp. lactis: purification and properties". Journal of Applied Bacteriology 68 (4): 357–366. 1990. doi:10.1111/j.1365-2672.1990.tb02886.x.
- ↑ "Cloning and sequence analysis of the X-prolyl-dipeptidyl-aminopeptidase gene (pepX) from Lactobacillus delbrückii ssp. lactis DSM7290". Applied Microbiology and Biotechnology 40 (1): 82–9. October 1993. doi:10.1007/bf00170433. PMID 7765315.
- ↑ "Purification and characterization of X-prolyl dipeptidyl peptidase from Lactobacillus casei subsp. casei LLG". Appl. Microbiol. Biotechnol. 42 (2–3): 280–286. 1994. doi:10.1007/s002530050250. PMID 7765768.
- ↑ "Preparation of bacterial X-prolyl dipeptidyl aminopeptidase and its stabilization by organic cosolvents". Analytical Biochemistry 224 (1): 245–9. January 1995. doi:10.1006/abio.1995.1036. PMID 7710078.
- ↑ "Identification of the active site serine of the X-prolyl dipeptidyl aminopeptidase from Lactococcus lactis". FEBS Letters 314 (2): 139–42. December 1992. doi:10.1016/0014-5793(92)80960-o. PMID 1459244.
External links
- Xaa-Pro+dipeptidyl-peptidase at the US National Library of Medicine Medical Subject Headings (MeSH)
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