Biology:Zinc D-Ala-D-Ala carboxypeptidase
From HandWiki
| Zinc D-Ala-D-Ala carboxypeptidase | |||||||||
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| Identifiers | |||||||||
| EC number | 3.4.17.14 | ||||||||
| CAS number | 213189-85-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Zinc D-Ala-D-Ala carboxypeptidase (EC 3.4.17.14, Zn2+ G peptidase, D-alanyl-D-alanine hydrolase, D-alanyl-D-alanine-cleaving carboxypeptidase, DD-carboxypeptidase, G enzyme, DD-carboxypeptidase-transpeptidase) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction
- Cleavage of the bond: (Ac)2-L-lysyl-D-alanyl--D-alanine
This is a zinc enzyme. Catalyses carboxypeptidation but not transpeptidation reactions involved in bacterial cell wall metabolism.
References
- ↑ "Structure of a Zn2+-containing D-alanyl-D-alanine-cleaving carboxypeptidase at 2.5 A resolution". Nature 299 (5882): 469–70. September 1982. doi:10.1038/299469a0. PMID 7121588. http://orbi.ulg.ac.be/handle/2268/77995.
- ↑ "The complete amino acid sequence of the Zn2+-containing D-alanyl-D-alanine-cleaving carboxypeptidase of streptomyces albus G". European Journal of Biochemistry 130 (1): 53–69. January 1983. doi:10.1111/j.1432-1033.1983.tb07116.x. PMID 6825689. http://orbi.ulg.ac.be/handle/2268/83018.
- ↑ "Bacterial wall peptidoglycan, DD-peptidases and beta-lactam antibiotics". Scandinavian Journal of Infectious Diseases. Supplementum 42: 17–37. 1984. PMID 6597561.
External links
- Zinc+D-Ala-D-Ala+carboxypeptidase at the US National Library of Medicine Medical Subject Headings (MeSH)
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