Chemistry:3-Methoxymorphinan
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Short description: Chemical compound
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| Formula | C17H23NO |
| Molar mass | 257.377 g·mol−1 |
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3-Methoxymorphinan is a levomethorphan metabolite that has been shown to produce local anesthetic effects.[1] It is the CYP3A4 metabolite of dextromethorphan,[2] and is itself metabolized by the liver enzyme CYP2D6.[3]
See also
- 3-hydroxymorphinan
- Dextrorphan
- Dextromethorphan
- Levomethorphan
- Morphinan
References
- ↑ "Dextromethorphan, 3-methoxymorphinan, and dextrorphan have local anaesthetic effect on sciatic nerve blockade in rats". European Journal of Pharmacology 544 (1–3): 10–16. August 2006. doi:10.1016/j.ejphar.2006.06.013. PMID 16844109.
- ↑ "A urine metabolic ratio of dextromethorphan and 3-methoxymorphinan as a probe for CYP3A activity and prediction of cyclosporine clearance in healthy volunteers". Pharmacotherapy 19 (6): 753–759. June 1999. doi:10.1592/phco.19.9.753.31536. PMID 10391422.
- ↑ "Dose-response relationship for the pharmacokinetic interaction of grapefruit juice with dextromethorphan investigated by human urinary metabolite profiles". Food and Chemical Toxicology 47 (8): 1928–1935. August 2009. doi:10.1016/j.fct.2009.05.004. PMID 19445995.
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