Chemistry:Azepinoindole
From HandWiki
Azepinoindole is a tricyclic chemical compound related to tryptamine and having various alkaloid derivatives.[1][2] The analogue of azepinoindole with the azepine ring fully hydrogenated, noribogaminalog (1,2,3,4,5,6-hexahydroazepino[4,5-b]indole), is a parent compound of the iboga-type alkaloids such as ibogaine, ibogamine, and tabernanthine as well as their simplified ibogalog analogues ibogainalog, ibogaminalog, and tabernanthalog.[1][3][4]
Chemical structures of selected azepinoindole derivatives
-
-
-
-
-
Ibogainalog -
See also
- Ibogalog
- Iboga-type alkaloid
- Desethylibogamine
- Substituted β-carboline
- PHA-57378
- PNU-22394
- PNU-181731
- Tryptoline
References
- ↑ 1.0 1.1 "The Iboga Alkaloids". Progress in the Chemistry of Organic Natural Products. 105. 2017. pp. 89–136. doi:10.1007/978-3-319-49712-9_2. ISBN 978-3-319-49711-2.
- ↑ "Non-monoterpenoid azepinoindole alkaloids". Nat Prod Rep 35 (12): 1347–1382. July 2018. doi:10.1039/c8np00047f. PMID 30024006.
- ↑ "DM506 (3-Methyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole fumarate), a Novel Derivative of Ibogamine, Inhibits α7 and α9α10 Nicotinic Acetylcholine Receptors by Different Allosteric Mechanisms". ACS Chem Neurosci 14 (14): 2537–2547. July 2023. doi:10.1021/acschemneuro.3c00212. PMID 37386821.
- ↑ "Azepinoindoles. I. Hexahydroazepino[4,5-b]indoles". J Med Chem 11 (1): 101–106. January 1968. doi:10.1021/jm00307a023. PMID 5637151.
 |
