Chemistry:PHA-57378

From HandWiki
Short description: Chemical compound
PHA-57378
PHA-57378.svg
Identifiers
CAS Number
PubChem CID
ChemSpider
Chemical and physical data
FormulaC14H16N2O
Molar mass228.295 g·mol−1
3D model (JSmol)

PHA-57378 is a drug which acts as an agonist at serotonin 5-HT2 receptors,[1] having a binding affinity of 4.1 nM at the 5-HT2A subtype and 4.3 nM at 5-HT2C. It has anxiolytic effects in animal studies.[2]

See also

References

  1. Hester JB, Rogers BN, Jacobsen EJ, Ennis MD, Acker BA, Van der Velde SL, Frank KE, "Tetracyclic Azepinoindole Compounds as 5-HT Receptor Ligands", WO patent application 2000064899, published 2 November 2000, assigned to Pharmacia Upjohn Company
  2. "2,3,4,5-tetrahydro- and 2,3,4,5,11,11a-hexahydro-1H-[1,4]diazepino[1,7-a]indoles: new templates for 5-HT(2C) agonists". Bioorganic & Medicinal Chemistry Letters 13 (14): 2369–72. July 2003. doi:10.1016/S0960-894X(03)00403-7. PMID 12824036.