Chemistry:Bay 1436032
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| Formula | C26H30F3N3O3 |
| Molar mass | 489.539 g·mol−1 |
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Bay 1436032 is an experimental anticancer drug which acts as an inhibitor of the enzyme isocitrate dehydrogenase 1. Mutations in this enzyme are often found in various types of cancer, especially leukemia. Bay 1436032 was unsuccessful in early stage clinical trials as a monotherapy, but continues to be researched in combination with other drugs.[1][2][3]
See also
References
- ↑ "Pan-mutant-IDH1 inhibitor BAY1436032 is highly effective against human IDH1 mutant acute myeloid leukemia in vivo". Leukemia 31 (10): 2020–2028. October 2017. doi:10.1038/leu.2017.46. PMID 28232670.
- ↑ "Synergistic activity of IDH1 inhibitor BAY1436032 with azacitidine in IDH1 mutant acute myeloid leukemia". Haematologica 106 (2): 565–573. February 2021. doi:10.3324/haematol.2019.236992. PMID 32241846.
- ↑ "Monitoring response to a clinically relevant IDH inhibitor in glioma-Hyperpolarized 13C magnetic resonance spectroscopy approaches". Neuro-Oncology Advances 5 (1). 2023. doi:10.1093/noajnl/vdad143. PMID 38024238.
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