Chemistry:Benexate

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Benexate
Benexate.png
Clinical data
AHFS/Drugs.comInternational Drug Names
Routes of
administration
Oral
ATC code
  • none
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
Chemical and physical data
FormulaC23H27N3O4
Molar mass409.486 g·mol−1
3D model (JSmol)
 ☒N☑Y (what is this?)  (verify)

Benexate (BEX) is an anti-ulcer agent used in the treatment of acid-related disorders. It is unique in its inability to form salts that are both non-bitter and soluble.[1][2]

Mechanism of action

Promotion of prostaglandin synthesis, protein secretion, and blood flow stimulation in the gastrointestinal tract.[3]

BEX-HCl forms an inclusion complex with β-cyclodextrin (image) to improve its solubility as well as uniquely functioning as an anti-bittering agent.
β-cyclodextrin

See also

References

  1. "Differential effect of benexate hydrochloride betadex on prostaglandin levels in stomach and inflammatory sites in rats". Japanese Journal of Pharmacology 72 (2): 183–190. 1996. doi:10.1254/jjp.72.183. PMID 8912919. 
  2. "Studies of benexate CD: effect of inclusion compound formation on the antiulcer activity of benexate, the effective ingredient of benexate CD.". Folia Pharmacologica Japonica (91): 377–383. 1998. 
  3. "Benexate hydrochloride betadex modulates nitric oxide synthesis and cytokine expression in gastric ulcers". Experimental and Therapeutic Medicine 12 (2): 573–580. 2016. doi:10.3892/etm.2016.3384. PMID 27446246. 

Further reading

Rui Tamura, Mikiji Miyata, ed (2015). Advances in Organic Crystal Chemistry: Comprehensive Reviews 2015 (1st ed.). Springer Japan. doi:10.1007/978-4-431-55555-1. ISBN 978-4-431-55554-4. https://www.springer.com/gp/book/9784431555544.