Chemistry:Butamirate
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Clinical data | |
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Trade names | Acodeen, Codesin, Pertix, Sinecod, Sinecoden, Sinecodix |
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Protein binding | 98% |
Elimination half-life | 6 hours |
Excretion | 90% renal |
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Chemical and physical data | |
Formula | C18H29NO3 |
Molar mass | 307.434 g·mol−1 |
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Butamirate (or brospamin, trade names Acodeen, Codesin, Pertix, Sinecod, Sinecoden, Sinecodix) is a cough suppressant.[1] It has been marketed in Europe and Mexico, but not in the United States.[2]
It is sold in the form of lozenges, syrup, tablets, dragées, or pastilles as the citrate salt. Adverse effects can include nausea, diarrhea, vertigo, and exanthema.[2]
Pharmacology
A study found it to bind to the cough center in the medulla oblongata, more specifically the dextromethorphan-binding site in guinea pig brain with high affinity.[3]
As a 2-(2-diethylaminoethoxy)ethyl ester, it is chemically related to oxeladin and pentoxyverine, which are in the same class. (Oxeladin has an additional ethyl group in its carboxylic acid, pentoxyverine has both ethyl groups of oxeladin replaced by one cyclopentyl in the same place.)
See also
- Cough syrup
- Noscapine
- Codeine; Pholcodine
- Dextromethorphan; Dimemorfan
- Racemorphan; Dextrorphan; Levorphanol
- Pentoxyverine
- Tipepidine
- Cloperastine; Levocloperastine
References
- ↑ "[Clinical comparison of butamirate citrate with a codeine-based antitussive agent]". Revue Médicale de la Suisse Romande 110 (11): 983–6. November 1990. PMID 1980027.
- ↑ 2.0 2.1 Drugs Available Abroad, 1st Edition. Derwent Publications Ltd.. 1991. pp. 29–30. ISBN 0-8103-7177-4.
- ↑ "High affinity dextromethorphan binding sites in guinea pig brain. Effect of sigma ligands and other agents". The Journal of Pharmacology and Experimental Therapeutics 251 (1): 207–15. October 1989. PMID 2477524.
![]() | Original source: https://en.wikipedia.org/wiki/Butamirate.
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