Chemistry:Dornase alfa
From HandWiki
Short description: Pharmaceutical drug
| Clinical data | |
|---|---|
| Trade names | Pulmozyme |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a694002 |
| License data | |
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| Routes of administration | Inhalation |
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| Legal status | |
| Legal status | |
| Identifiers | |
| CAS Number | |
| DrugBank | |
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| Chemical and physical data | |
| Formula | C1321H1999N339O396S9 |
| Molar mass | 29254.04 g·mol−1 |
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Dornase alfa, sold under the brand name Pulmozyme, is used for the treatment of cystic fibrosis.[3] It is a recombinant human deoxyribonuclease I (rhDNase), an enzyme which selectively cleaves DNA.[3] Dornase alfa hydrolyzes the DNA present in sputum/mucus and reduces viscosity in the lungs, promoting improved clearance of secretions.[3] It is produced in Chinese hamster ovary cells.[3]
Medical uses
Dornase alfa is indicated for the management of people with cystic fibrosis to improve pulmonary function.[3]
Society and culture
Legal status
Dornase alfa is an orphan drug.[4]
Research
Dornase alfa has been shown to improve lung function in non-cystic fibrosis pre-term infants atelectasis.[5][6]
References
- ↑ 1.0 1.1 Product guildlink.com.au
- ↑ "Pulmozyme Product information". 25 April 2012. https://health-products.canada.ca/dpd-bdpp/info.do?lang=en&code=15483.
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 "Pulmozyme- dornase alfa solution". 21 October 2020. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d8c78a7e-ff99-48f3-8952-643ec2ea0f86.
- ↑ Collier, Joe (1 September 1995). "Dornase-alfa and orphan drugs". The Lancet 346 (8975): 633. doi:10.1016/S0140-6736(95)91460-9. PMID 7651014.
- ↑ "Efficacy and safety of nebulized recombinant human DNase as rescue treatment for persistent atelectasis in newborns: case-series.". Croat Med J 48 (2): 234–9. 2007. PMID 17436388.
- ↑ "DNase and atelectasis in non-cystic fibrosis pediatric patients.". Crit Care 9 (4): R351-6. 2005. doi:10.1186/cc3544. PMID 16137347.
de:Desoxyribonuklease#Verwendung als Arzneistoff
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