Chemistry:Cerebral vasodilator

From HandWiki
Short description: Drug that increases brain blood flow
Cerebral vasodilator
Drug class
Class identifiers
UseTo treat cerebrovascular insufficiency
Mode of actionIncrease blood flow to the brain

A cerebral vasodilator is a drug which acts as a vasodilator in the brain.[1][2] They are used to improve blood flow in people with cerebrovascular insufficiency and to treat neurological disorders secondary to this condition.[2] A number of different cerebral vasodilators exist.[2][1][3] An example is ifenprodil, which has been marketed for use as a cerebral vasodilator in France, Hong Kong, and Japan.[4][5][6] Other examples include buphenine (nylidrin), isoxsuprine, oxyfedrine, suloctidil, and tinofedrine.[7]

Similar drugs include cerebral activators, or cerebral metabolism activators, like bifemelane, indeloxazine, and teniloxazine, which are also used to treat cerebrovascular disease.[8][9][10][11]

See also

References

  1. ↑ 1.0 1.1 "Cerebral vasodilators". Jpn J Pharmacol 76 (4): 349–367. April 1998. doi:10.1254/jjp.76.349. PMID 9623714. 
  2. ↑ 2.0 2.1 2.2 "Drug therapy: cerebral vasodilators (first of two parts)". N Engl J Med 305 (25): 1508–1513. December 1981. doi:10.1056/NEJM198112173052505. PMID 7029283. 
  3. ↑ "Vasodilators in senile dementias: a review of the literature". Arch Gen Psychiatry 36 (2): 220–223. February 1979. doi:10.1001/archpsyc.1979.01780020110012. PMID 420543. 
  4. ↑ "NMDA Receptor Antagonists: Emerging Insights into Molecular Mechanisms and Clinical Applications in Neurological Disorders". Pharmaceuticals (Basel) 17 (5): 639. May 2024. doi:10.3390/ph17050639. PMID 38794209. 
  5. ↑ "Effects of transient global ischemia and a monoamine oxidase inhibitor ifenprodil on rat brain monoamine metabolism". Prog Brain Res 106: 173–80. 1995. doi:10.1016/s0079-6123(08)61213-3. PMID 8584652. 
  6. ↑ Schweizerischer Apotheker-Verein (2004). Index Nominum: International Drug Directory. Medpharm Scientific Publishers. p. 625. ISBN 978-3-88763-101-7. https://books.google.com/books?id=EgeuA47Ocm4C&pg=PA625. Retrieved 2 September 2024. 
  7. ↑ Braestrup, C. (2012). Psychotropic Agents: Part II: Anxiolytics, Gerontopsychopharmacological Agents, and Psychomotor Stimulants. Handbook of Experimental Pharmacology. Springer Berlin Heidelberg. pp. 419–420. ISBN 978-3-642-67767-0. https://books.google.com/books?id=tVbmCAAAQBAJ&pg=PA419. Retrieved 17 October 2024. 
  8. ↑ "Clinical pharmacology of senile dementia". Prog Neuropsychopharmacol 5 (5–6): 447–457. 1981. doi:10.1016/0364-7722(81)90026-6. PMID 6122228. 
  9. ↑ Yamamoto, M; Kawabata, S; Shimizu, M (1989). "Pharmacological effects of indeloxazine, a new cerebral activator, on brain functions distinct from other cerebral metabolic enhancers". Neuropharmacology 28 (12): 1291–1297. doi:10.1016/0028-3908(89)90001-4. ISSN 0028-3908. PMID 2615913. 
  10. ↑ Takahashi, Koichiro; Yamamoto, Minoru; Suzuki, Masanori; Ozawa, Yukiko; Yamaguchi, Takashi; Andoh, Hirofumi; Ishikawa, Kouichi (1995). "Effects of cerebral metabolic enhancers on brain function in rodents". Current Therapeutic Research 56 (5): 478–485. doi:10.1016/0011-393X(95)85080-5. ISSN 0011-393X. 
  11. ↑ "Cognition-enhancing drugs in dementia: a guide to the near future". Can J Psychiatry 42 (Suppl 1): 35S–50S. 1997. PMID 9220128. 



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