Chemistry:Ceruletide
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| Formula | C58H73N13O21S2 |
| Molar mass | 1352.41 g·mol−1 |
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Ceruletide (INN), also known as cerulein or caerulein, is a ten amino acid oligopeptide that stimulates smooth muscle and increases digestive secretions. Ceruletide is similar in action and composition to cholecystokinin. It stimulates gastric, biliary, and pancreatic secretion; and certain smooth muscle. It is used in paralytic ileus and as diagnostic aid in pancreatic malfunction. It is used to induce pancreatitis in experimental animal models.
Ceruletide was discovered and its structure elucidated in 1967 by Australian and Italian scientists from dried skins of the Australian green tree frog (Ranoidea caerulea, formerly Hyla caerulea). Its amino acid sequence is Pglu-Gln-Asp-Tyr[SO3H]-Thr-Gly-Trp-Met-Asp-Phe-NH2.[1][2]
Induction of pancreatitis
Ceruletide upregulates pancreatic acinar cell intercellular adhesion molecule-1 (ICAM-1) proteins through intracellular upregulation of NF-κB. Surface ICAM-1 in turn promotes neutrophil adhesion onto acinar cells enhancing pancreatic inflammation.[3] In addition to promoting the inflammatory cell reaction to acinar cells, ceruletide induces pancreatitis through dysregulation of digestive enzyme production and cytoplasmic vacuolization, leading to acinar cell death and pancreatic edema. Ceruletide also activates NADPH oxidase, a source of reactive oxygen species contributing to inflammation, as well as the Janus kinase/signal transducer, another inflammation inducer.[4]
See also
References
- ↑ "Isolation and structure of caerulein, an active decapeptide from the skin of Hyla caerulea". Experientia 23 (9): 699–700. September 1967. doi:10.1007/BF02154119. PMID 6062875.
- ↑ "Occurrence of caerulein in extracts of the skin of Hyla caerulea and other Australian hylids". British Journal of Pharmacology and Chemotherapy 33 (1): 48–58. May 1968. doi:10.1111/j.1476-5381.1968.tb00473.x. PMID 5660165.
- ↑ "Cerulein upregulates ICAM-1 in pancreatic acinar cells, which mediates neutrophil adhesion to these cells". American Journal of Physiology. Gastrointestinal and Liver Physiology 279 (4): G666-76. October 2000. doi:10.1152/ajpgi.2000.279.4.G666. PMID 11005752. http://ajpgi.physiology.org/content/279/4/G666.full.pdf+html.
- ↑ "Cerulein pancreatitis: oxidative stress, inflammation, and apoptosis". Gut and Liver 2 (2): 74–80. September 2008. doi:10.5009/gnl.2008.2.2.74. PMID 20485614.
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