Chemistry:DAPT (chemical)
From HandWiki
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| Systematic IUPAC name
tert-Butyl (S)-{(2S)-2-[2-(3,5-difluorophenyl)acetamido]propanamido}phenylacetate | |
| Other names
gamma-Secretase Inhibitor IX; GSI-IX; LY-374973; N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester
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| Identifiers | |
3D model (JSmol)
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PubChem CID
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| Properties | |
| C23H26F2N2O4 | |
| Molar mass | 432.468 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| Infobox references | |
Tracking categories (test):
DAPT is a chemical compound used in the study of the Notch signaling pathway.[1] DAPT is a γ-secretase inhibitor. It indirectly inhibits Notch, which is a substrate for γ-secretase.[2]
In a mouse model of Alzheimer's disease, DAPT reduces the levels of beta-amyloid.[3]
References
- ↑ Geling, A.; Steiner, H.; Willem, M.; Bally-Cuif, L.; Haass, C. (2002). "A gamma-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish". EMBO Reports 3 (7): 688–694. doi:10.1093/embo-reports/kvf124. PMID 12101103.
- ↑ "DAPT". Sigma-Aldrich. https://www.sigmaaldrich.com/catalog/product/sigma/d5942.
- ↑ Dovey, H. F.; John, V.; Anderson, J. P.; Chen, L. Z.; De Saint Andrieu, P.; Fang, L. Y.; Freedman, S. B.; Folmer, B. et al. (2001). "Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain". Journal of Neurochemistry 76 (1): 173–81. doi:10.1046/j.1471-4159.2001.00012.x. PMID 11145990.
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