Chemistry:Denaverine
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Short description: Chemical compound
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| Routes of administration | intramuscular injection, suppositories |
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| Bioavailability | 8% (suppositories), 37% (oral solution) |
| Metabolism | mainly hepatic, at least 11 metabolites |
| Elimination half-life | 34 hours |
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| Formula | C24H33NO3 |
| Molar mass | 383.532 g·mol−1 |
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Denaverine is an antispasmodic drug. It was developed in Germany and patented in 1974. Denaverine hydrochloride is used in veterinary medicine under the trade name Sensiblex as a muscle relaxant for the myometrium of cows and dogs during parturition.[1] Under the trade name Spasmalgan, it has also been used in humans for the treatment of urogenital and gastrointestinal spasms.[2]
Mechanism of action
Denaverine, like papaverine, acts as a phosphodiesterase inhibitor. Additionally, it has anticholinergic effects.[3]
References
- ↑ Committee for Veterinary Medicinal Products: Denavering Hydrochloride Summary Report
- ↑ (in German) Rote Liste (2005 ed.). Aulendorf: Editio Cantor. 2005. 77 023. ISBN 3-87193-306-6.
- ↑ (in German) Arzneistoff-Profile. 4 (23 ed.). Eschborn, Germany: Govi Pharmazeutischer Verlag. 2010. ISBN 978-3-7741-9846-3.
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