Chemistry:Donafenib
From HandWiki
Donafenib, sold under the brand name Zepsun, is a pharmaceutical drug for the treatment of cancer.
In China, donafenib is approved for the treatment of unresectable hepatocellular carcinoma in patients who have not previously received systemic treatment.[1][2]
Donafenib is a kinase inhibitor that targets Raf kinase and various receptor tyrosine kinases.[3] It is a deuterated derivative of sorafenib with improved pharmacokinetic properties.[4][5]
References
- ↑ "Donafenib: First Approval". Drugs 81 (16): 1915–1920. November 2021. doi:10.1007/s40265-021-01603-0. PMID 34591285.
- ↑ "Donafenib in hepatocellular carcinoma". Drugs of Today 59 (2): 83–90. February 2023. doi:10.1358/dot.2023.59.2.3507751. PMID 36811408.
- ↑ "Donafenib". NCI Cancer Dictionary. National Cancer Institute, National Institutes of Health. https://www.cancer.gov/publications/dictionaries/cancer-drug/def/donafenib.
- ↑ "Donafenib Versus Sorafenib in First-Line Treatment of Unresectable or Metastatic Hepatocellular Carcinoma: A Randomized, Open-Label, Parallel-Controlled Phase II-III Trial". Journal of Clinical Oncology 39 (27): 3002–3011. September 2021. doi:10.1200/JCO.21.00163. PMID 34185551.
- ↑ "P-86 Comparison of the pharmacokinetics of donafenib and sorafenib in patients with advanced hepatocellular carcinoma: An open-label, randomized, parallel-controlled, multicentre phase II/III trial". Annals of Oncology 31: S117–S118. 2020. doi:10.1016/j.annonc.2020.04.168.
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