Chemistry:GRL-0617
From HandWiki
Short description: Chemical compound
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| Formula | C20H20N2O |
| Molar mass | 304.393 g·mol−1 |
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GRL-0617 is a drug which is one of the first compounds discovered that acts as a selective small-molecule inhibitor of the protease enzyme papain-like protease (PLpro) found in some pathogenic viruses, including the coronavirus SARS-CoV-2. It has been shown to inhibit viral replication in silico [1] and in vitro.[2][3][4][5]
See also
- 3CLpro-1
- Ebselen
- GC376
References
- ↑ "Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties". New Journal of Chemistry 44 (22): 9202–9212. May 2020. doi:10.1039/D0NJ00974A.
- ↑ "Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity". Nature 587 (7835): 657–662. November 2020. doi:10.1038/s41586-020-2601-5. PMID 32726803. Bibcode: 2020Natur.587..657S.
- ↑ "Establishing an Analogue Based In Silico Pipeline in the Pursuit of Novel Inhibitory Scaffolds against the SARS Coronavirus 2 Papain-Like Protease". Molecules 26 (4): 1134. February 2021. doi:10.3390/molecules26041134. PMID 33672721. PMC 7924369. https://www.repository.cam.ac.uk/bitstream/handle/1810/318010/molecules-26-01134-v2.pdf?sequence=3&isAllowed=y.
- ↑ "Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp3 papain-like protease". The Biochemical Journal 478 (13): 2517–2531. July 2021. doi:10.1042/BCJ20210244. PMID 34198325.
- ↑ "Recent advances in developing small-molecule inhibitors against SARS-CoV-2". Acta Pharmaceutica Sinica B 12 (4): 1591–1623. July 2021. doi:10.1016/j.apsb.2021.06.016. PMID 34249607.
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