Chemistry:Muscazone

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Muscazone is an amino acid derivative found in Amanita muscaria (fly agaric) mushrooms.[1] It is a photodegradation product of ibotenic acid.[2] The human psychoactivity of muscazone is unknown, but it is said to have weak activity in neurochemical tests.[3] Muscazone was first described in the scientific literature by 1965.[4][5][6] Other notable compounds found in Amanita muscaria include ibotenic acid, muscimol, and muscarine.[3]

Amanita muscaria contains muscazone.

See also

References

  1. ↑ Cite error: Invalid <ref> tag; no text was provided for refs named Merck
  2. ↑ Ordak, Michal (26 May 2026). "Amanita muscaria in the evolving novel psychoactive substances landscape - toxicological risks and clinical implications: a narrative review". Frontiers in Pharmacology 17. doi:10.3389/fphar.2026.1838212. ISSN 1663-9812. 
  3. ↑ 3.0 3.1 "Ibotenic Acid–Muscimol: The Primordial Pangk and Amrta". Pharmacotheon: Entheogenic Drugs, Their Plant Sources and History (2 ed.). Natural Products Company. 1996. pp. 323–358, 446. ISBN 978-0-9614234-8-3. https://anthrome.wordpress.com/wp-content/uploads/2010/06/pharmacotheon.pdf#page=223. "33. MUSCAZONE [...] Pharmacology: human activity unknown but has weak activity in neurochemical tests (Lanthorn, Searle Co., unpublished communication, Oct. 1986)." 
  4. ↑ "Isolierung und Charakterisierung von Prämuscimol und Muscazon aus Amanita muscaria (L. ex FR.) HOOKER" (in German). Helv Chim Acta 48: 927–930. June 1965. doi:10.1002/hlca.19650480428. PMID 14321964. 
  5. ↑ "Wirkstoffe aus Amanita muscaria: ibotensaeure und muscazon" (in German). Tetrahedron Lett (23): 1813–1815. June 1965. doi:10.1016/s0040-4039(00)90133-3. PMID 5891631. 
  6. ↑ Fritz, H., Gagneux, A. R., Zbinden, R., Geigy, J. R., Basle, S. A., & Eugster, C. H. (1965). The structure of muscazone. Tetrahedron Letters, 6(25), 2075–2076. https://scholar.google.com/scholar?cluster=5563476291089816824



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