Chemistry:NNC 26-9100
From HandWiki
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| Formula | C22H25BrCl2N6S |
| Molar mass | 556.35 g·mol−1 |
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NNC 26-9100 is a chemical compound which acts as an agonist at somatostatin receptor 4. It has been researched for potential applications in the treatment of Alzheimer's disease, and has positive effects on learning and memory in animal studies.[1][2][3][4]
See also
- J-2156
- Mazisotine
References
- ↑ "2-pyridylthioureas: novel nonpeptide somatostatin agonists with SST4 selectivity". Current Pharmaceutical Design 5 (4): 255–263. April 1999. doi:10.2174/1381612805666230109213422. PMID 10101224.
- ↑ "Chronic peripheral administration of somatostatin receptor subtype-4 agonist NNC 26-9100 enhances learning and memory in SAMP8 mice". European Journal of Pharmacology 654 (1): 53–59. March 2011. doi:10.1016/j.ejphar.2010.12.013. PMID 21185826.
- ↑ "Somatostatin Receptor Subtype-4 Regulates mRNA Expression of Amyloid-Beta Degrading Enzymes and Microglia Mediators of Phagocytosis in Brains of 3xTg-AD Mice". Neurochemical Research 44 (11): 2670–2680. November 2019. doi:10.1007/s11064-019-02890-6. PMID 31630317.
- ↑ "NNC 26-9100 increases Aβ1-42 phagocytosis, inhibits nitric oxide production and decreases calcium in BV2 microglia cells". PLOS ONE 16 (7). 2021. doi:10.1371/journal.pone.0254242. PMID 34237100.
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