Chemistry:Off-target activity
From HandWiki
Short description: Drug biological activity
Off-target activity is biological activity of a drug that is different from and not at that of its intended biological target. It most commonly contributes to side effects. However, in some cases, off-target activity can be taken advantage of for therapeutic purposes. An example of this is the repurposing of the antimineralocorticoid and diuretic spironolactone, which was found to produce feminization and gynecomastia as side effects, for use as an antiandrogen in the treatment of androgen-dependent conditions like acne and hirsutism in women.[1]
See also
References
- ↑ "Applications of Genome-Wide Screening and Systems Biology Approaches in Drug Repositioning". Cancers (Basel) 12 (9): 2694. September 2020. doi:10.3390/cancers12092694. PMID 32967266.
Original source: https://en.wikipedia.org/wiki/Off-target activity.
Read more |