Chemistry:P-Phenetidine
From HandWiki
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| Names | |
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| Preferred IUPAC name
4-Ethoxyaniline | |
| Other names
para-Phenetidine; 4-Aminophenetole
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| Identifiers | |
3D model (JSmol)
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| ChEBI | |
| ChEMBL | |
| ChemSpider | |
| EC Number |
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PubChem CID
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| RTECS number |
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| UNII | |
| UN number | 2311 |
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| Properties | |
| C8H11NO | |
| Molar mass | 137.182 g·mol−1 |
| Appearance | Colorless liquid; turns red to brown on exposure to air[1] |
| Density | 1.07 g/mL[2] |
| Melting point | 3 °C (37 °F; 276 K)[2] |
| Boiling point | 254 °C (489 °F; 527 K)[2] |
| 20 g/L (20 °C)[2] | |
| Hazards | |
| GHS pictograms |  
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| GHS Signal word | Warning |
| H302, H312, H317, H319, H332, H341 | |
| P203Script error: No such module "Preview warning".Category:GHS errors, P261, P264, P264+265Script error: No such module "Preview warning".Category:GHS errors, P270, P271, P272, P280, P301+317Script error: No such module "Preview warning".Category:GHS errors, P302+352, P304+340, P305+351+338, P317Script error: No such module "Preview warning".Category:GHS errors, P318Script error: No such module "Preview warning".Category:GHS errors, P321, P330, P333+317Script error: No such module "Preview warning".Category:GHS errors, P337+317Script error: No such module "Preview warning".Category:GHS errors, P362+364Script error: No such module "Preview warning".Category:GHS errors, P405, P501 | |
| Flash point | 116 °C (241 °F; 389 K)[2] |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| Infobox references | |
Tracking categories (test):
p-Phenetidine (4-ethoxyaniline) is a chemical compound with the molecular formula C8H11NO. It is one of the three isomers of phenetidine. It is used as an intermediate in the synthesis of pharmaceutical drugs, dyes, and the sweetener dulcin.[1]
p-Phenetidine is a metabolite of the pharmaceutical drugs bucetin and phenacetin[3] and of the preservative ethoxyquin.[4] It is also used as a chemical intermediate in the manufacture of bucetin, phenacetin, ethoxyquin, and phenacaine.
p-Phenetidine has high renal toxicity[3] and it is believed to be responsible for the adverse effects that led to the withdrawal of phenacetin and bucetin from pharmaceutical use. p-Phenetidine is also a possible mutagen.[4]
References
- ↑ 1.0 1.1 Merck Index (12th ed.). p. 1244. 7373. p-Phenetidine.
- ↑ 2.0 2.1 2.2 2.3 2.4 Record in the GESTIS Substance Database of the Institute for Occupational Safety and Health
- ↑ 3.0 3.1 Kankuri, Esko; Solatunturi, Erkka; Vapaatalo, Heikki (2003). "Effects of phenacetin and its metabolite p-phenetidine on COX-1 and COX-2 activities and expression in vitro". Thrombosis Research 110 (5–6): 299–303. doi:10.1016/S0049-3848(03)00416-X. PMID 14592552.
- ↑ 4.0 4.1 "Ethoxyquin: EFSA safety assessment inconclusive". European Food Safety Authority. 2015-11-18. http://www.efsa.europa.eu/en/press/news/151118.
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