Chemistry:Pentastack

From HandWiki

The pentastack is a hazardous five-drug mixture discussed in online looksmaxxing communities that combines powerful stimulants and severe central nervous system depressants. It consists of: Adderall, dextromethorphan, pregabalin, ketamine and BDO (1,4-Butanediol).[1] It has been compared to the date rape drug Rohypnol by Vanity Fair.[1][2]

Origin

In 2026, Androgenic, an Australian looksmaxxing influencer, revealed the "pentastack", a list of five substances which he uses while livestreaming.[2]

Adderall, Dextromethorphan and Ketamine are fairly common off-the-shelf pharmaceuticals with legitimate medical use. Pregabalin (under the brand name Lyrica) is a drug used to treat epilepsy and other nervous damages, and has sedative effects[3][4][5][6]. 1,4-Butanediol (with street names like "Bute", "One Comma Four" or "Liquid Fantasy") is a chemical that exerts similar euphoric effects to its metabolite, GABA analogue gamma-hydroxybutyrate (GHB).[7] BDO can cause seizures, nausea, vomiting, and withdrawal symptoms can potentially cause death.[8]

Issues

On April 14, 2026, looksmaxxing influencer Clavicular overdosed on a Kick livestream with Androgenic, after he took a combination of the pentastack. The livestream ended, and he was rushed to the hospital. After Androgenic's pentastack video resurfaced, he defended his consumption, claiming it was less harmful than mixing alcohol with cocaine, and describing it as his: "high IQ healthy sustainable drug stack"[2][9][10]

See also

References

  1. ↑ 1.0 1.1 Wilkins, Joe (2026-05-03). "The "Pentastack" of Illegal Drugs That Looksmaxxers Like Clavicular Are Taking to Enjoy a Night Out Sounds Like a One-Way Trip to the Hospital" (in en-US). https://futurism.com/health-medicine/pentastack-drugs-looksmaxxing. 
  2. ↑ 2.0 2.1 2.2 Vanderhoof, Erin (2026-04-29). "Peptides, Supplements, and the Pentastack: The Unholy Guide to Looksmaxxing" (in en-US). https://www.vanityfair.com/news/story/the-unholy-guide-to-looksmaxxing. 
  3. ↑ "Pregabalin". The American Society of Health-System Pharmacists. https://www.drugs.com/monograph/pregabalin.html. 
  4. ↑ "Pregabalin: a review of its use in adults with generalized anxiety disorder". CNS Drugs 28 (9): 835–854. September 2014. doi:10.1007/s40263-014-0192-0. PMID 25149863. 
  5. ↑ "Gabapentin enacarbil, pregabalin and rotigotine are equally effective in restless legs syndrome: a comparative meta-analysis". European Journal of Neurology 24 (12): 1446–1456. December 2017. doi:10.1111/ene.13449. PMID 28888061. 
  6. ↑ "Chapter 28 - Herpes Zoster and Postherpetic Neuralgia". Essentials of Pain Medicine (Fourth ed.). Elsevier. January 1, 2018. pp. 233–240.e2. doi:10.1016/b978-0-323-40196-8.00028-0. ISBN 978-0-323-40196-8. 
  7. ↑ Liakoni, Evangelia; Gugelmann, Hallam; Dempsey, Delia A.; Wiegand, Timothy J.; Havel, Christopher; Jacob, Peyton; Benowitz, Neal L. (2019-05). "Butanediol Conversion to Gamma-Hydroxybutyrate Markedly Reduced by the Alcohol Dehydrogenase Blocker Fomepizole". Clinical Pharmacology and Therapeutics 105 (5): 1196–1203. doi:10.1002/cpt.1306. ISSN 1532-6535. PMID 30450642. PMC 6465153. https://pmc.ncbi.nlm.nih.gov/articles/PMC6465153/. 
  8. ↑ Skryabin, VYu; Shevtsova, YuB; Novoselova, E. A. (2023-12-04). "Consequences of 1,4-Butanediol Misuse: A Review". Psychopharmacology Bulletin 53 (4): 48–53. doi:10.64719/pb.4475. ISSN 2472-2448. PMID 38076667. PMC 10698855. https://pmc.ncbi.nlm.nih.gov/articles/PMC10698855/. 
  9. ↑ Team, Looksmaxxing guide Editorial (2026-05-17). "What Was in Clavicular's 'Pentastack' — and Why It Almost Killed Him" (in en). https://looksmaxxing.guide/en/looks/clavicular-overdose-pentastack-explained/. 
  10. ↑ Team, Looksmaxxing guide Editorial (2026-05-17). "What Was in Clavicular's 'Pentastack' — and Why It Almost Killed Him" (in en). https://looksmaxxing.guide/en/looks/clavicular-overdose-pentastack-explained/. 
  • DEA - 1,4-Butanediol [1]



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