Chemistry:Pipethiaden

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Pipethiaden is a benzothiepin-based drug candidate that was at one time studied as a potential preventive to reduce the frequency of recurrent migraine headaches. It also has some activity as an antihistamine and is also an antagonist at the 5-HT2A and 5HT2C receptors.[1]

Synthesis:[2] Review:[3]

References

  1. ↑ "[Anti-allergic properties of pipethiaden--a new preventive agent for migraine]" (in Czech). Ceskoslovenska Farmacie 38 (6): 264–8. July 1989. PMID 2790993. 
  2. ↑ "Antiaminic agents derived from thieno[2,3-c]-2-benzothiepin: 4-(1-Methyl-4-piperidylidene)-4,9-dihydrothieno[2,3-c]-2-benzothiepin and some related compounds". Collection of Czechoslovak Chemical Communications 48 (2): 623–641. 1983. doi:10.1135/cccc19830623. 
  3. ↑ "Pipethiadene Tartrate". Drugs of the Future 8 (4): 334. 1983. doi:10.1358/dof.1983.008.04.65210. 




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