Chemistry:PyBOP

PyBOP

Names
IUPAC name (Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate
Other names PyBOP
Identifiers
CAS Number	128625-52-5 N
3D model (JSmol)	Interactive image
ChemSpider	2006820 Y
PubChem CID	2724699
UNII	Y6KQR4GY6T Y
InChI InChI=1S/C18H28N6OP.F6P/c1-2-10-18-17(9-1)19-20-24(18)25-26(21-11-3-4-12-21,22-13-5-6-14-22)23-15-7-8-16-23;1-7(2,3,4,5)6/h1-2,9-10H,3-8,11-16H2;/q+1;-1 Y Key: VIAFLMPQBHAMLI-UHFFFAOYSA-N Y InChI=1/C18H28N6OP.F6P/c1-2-10-18-17(9-1)19-20-24(18)25-26(21-11-3-4-12-21,22-13-5-6-14-22)23-15-7-8-16-23;1-7(2,3,4,5)6/h1-2,9-10H,3-8,11-16H2;/q+1;-1 Key: VIAFLMPQBHAMLI-UHFFFAOYAY
SMILES F[P-](F)(F)(F)(F)F.n4nn(O[P+](N1CCCC1)(N2CCCC2)N3CCCC3)c5ccccc45
Properties
Chemical formula	C18H28F6N6OP2
Molar mass	520.401 g·mol−1
Appearance	White crystals
Melting point	150 °C (302 °F; 423 K)
Hazards
Main hazards	Irritant
GHS pictograms
GHS Signal word	Warning
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

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PyBOP (benzotriazol-1-yloxytripyrrolidinophosphonium hexafluorophosphate) is a peptide coupling reagent used in solid phase peptide synthesis. It is used as a substitute for the BOP reagent - avoiding the formation of the carcinogenic waste product HMPA.

See also

• BOP reagent
• DEPBT, a related reagent that contains no phosphorus-nitrogen bonds
• HATU
• HBTU