Chemistry:Roche ester
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(R)- and (S)-enantiomers of Roche ester
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Names | |
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Preferred IUPAC name
Methyl 3-hydroxy-2-methylpropanoate | |
Identifiers | |
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3D model (JSmol)
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ChemSpider | |
PubChem CID
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UNII | |
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Properties | |
C5H10O3 | |
Molar mass | 118.13 gmol−1 |
Density | 1.071 g/mL |
Boiling point | 74 °C (165 °F; 347 K) at 10 mmHg |
Hazards | |
Flash point | 80 °C (176 °F; 353 K) |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
Infobox references | |
Roche ester (methyl 3-hydroxy-2-methylpropionate) is a chemical compound with formula C5H10O3. It can exist as two enantiomers. Both are commercially available and have been widely used as starting blocks for the synthesis of many targets including dictyostatin,[1] discodermolide[2] and spongidepsin.[3]
References
- ↑ Shin, Youseung; Fournier, Jean-Hugues; Fukui, Yoshikazu; Brückner, Arndt; Curran, Dennis (2004). "Total Synthesis of (−)-Dictyostatin: Confirmation of Relative and Absolute Configurations". Angewandte Chemie International Edition (Wiley) 43 (35): 4634–4637. doi:10.1002/anie.200460593. PMID 15316999.
- ↑ Paterson, Ian; Florence, Gordon (2003). "The Development of a Practical Total Synthesis of Discodermolide, a Promising Microtubule-Stabilizing Anticancer Agent". European Journal of Organic Chemistry (Wiley) 2003 (12): 2193–2208. doi:10.1002/ejoc.200300061.
- ↑ Ferrié, Laurent; Reymond, Sébastien; Capdevielle, Patrice; Cossy, Janine (2006). "Total Synthesis of (−)-Spongidepsin". Organic Letters (American Chemical Society) 8 (16): 3441–3443. doi:10.1021/ol061029w. PMID 16869630.
External links
Original source: https://en.wikipedia.org/wiki/Roche ester.
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