Chemistry:SRT1460

From HandWiki
Short description: Chemical compound
SRT1460
SRT-1460 structure.png
Identifiers
CAS Number
ChemSpider
Chemical and physical data
FormulaC26H29N5O4S
Molar mass507.61 g·mol−1
3D model (JSmol)

SRT1460 is a drug in development by Sirtris Pharmaceuticals intended as a small-molecule activator of the sirtuin subtype SIRT1. It has similar activity in animal studies to the known SIRT1 activator resveratrol, but is closer in potency to SRT1720. In animal studies it was found to improve insulin sensitivity and lower plasma glucose levels in fat, muscle and liver tissue, and increased mitochondrial and metabolic function.[1] However, the claim that SRT1460 is a SIRT1 activator has been questioned[2] and further defended.[3]

See also

References