Chemistry:Speedball (drug)

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Short description: Combination of narcotics
"Speedball"
Cocaine powder
Heroin powder

Speedball, powerball, or over and under[1] is the polydrug mixture of a stimulant with a depressant, usually an opioid. The most well-known mixture used for recreational drug use is that of cocaine and heroin; however, amphetamines can also be mixed with morphine and/or fentanyl. A speedball may be taken intravenously or by nasal insufflation.[2]

Speedballs often give stronger effects than either drug when taken alone due to drug synergy, and are a particularly hazardous mixture that can easily cause heart attack, respiratory arrest and death.[3] When compared to single drugs, speedballs are more likely to lead to addiction,[4][5] and users are more likely to relapse[4][6] and also to overdose.[7][8][9]

History

Original speedball combinations used methamphetamine mixed with heroin,[10] or cocaine hydrochloride mixed with morphine sulfate.[11]

Physiological response

Cocaine acts as a stimulant, whereas heroin/morphine acts as a depressant. Co-administration is meant to provide an intense rush of euphoria with a high that is supposed to combine the effects of both drugs, while hoping to reduce the negative effects, such as the anxiety, hypertension and palpitations associated with stimulants, and sedation/drowsiness from the depressant.

By suppressing the typical negative side effects of the two drugs, the user may falsely believe they have a higher tolerance, or that they are less intoxicated than they actually are. This can cause users to misjudge the intake of one or both of the drugs, resulting in a fatal overdose.

Super speedballs

The United States Drug Enforcement Administration warned in 2019 that the rapid rise of fentanyl supply in the country has led to combinations of both fentanyl and heroin with cocaine ("super speedballs"). In addition, the cross-contamination of powdered fentanyl into cocaine supplies has led to reports of cocaine users unknowingly consuming a speedball-like combination.[10]

Notable deaths attributed to speedball use

Notable incidents of use

In 1996, Steven Adler had a stroke after taking a speedball, leaving him with a permanent speech impediment.[33] That same year, Dave Gahan suffered a heart attack following a speedball overdose, but survived.[34] According to his autobiography, Slash experienced cardiac arrest for eight minutes after taking a speedball, but was revived.[35][when?]

See also

References

  1. ↑ "Drugs slang: what police must learn - I to Q". https://www.telegraph.co.uk/news/uknews/law-and-order/6521761/Drugs-slang-what-police-must-learn-I-to-Q.html. 
  2. ↑ Martin, Peter R.; Weinberg, Bennett Alan; Bealer, Bonnie K. (2007). Healing Addiction: An Integrated Pharmacopsychosocial Approach to Treatment. Hoboken, New Jersey: Wiley-Interscience. p. 122. ISBN 978-0-47165-630-2. https://archive.org/details/healingaddiction0000mart. 
  3. ↑ Martin, Peter; Weinberg, Bennett Alan; Bealer, Bonnie K. (2007). Healing Addiction: An Integrated Pharmacopsychosocial Approach to Treatment. Wiley. p. 122. ISBN 9780470082737. 
  4. ↑ 4.0 4.1 Duvauchelle, Christine L.; Sapoznik, Tova; Kornetsky, Conan (1998). "The synergistic effects of combining cocaine and heroin ("speedball") using a progressive-ratio schedule of drug reinforcement. Pharmacology Biochemistry and Behavior". Pharmacology Biochemistry and Behavior 61 (3): 297–302. doi:10.1016/S0091-3057(98)00098-7. PMID 9768564. 
  5. ↑ Hunt, Dana E.; Lipton, Douglas S; Goldsmith, Douglas; Strug, David (1984). "Street pharmacology: Uses of cocaine and heroin in the treatment of addiction". Drug and Alcohol Dependence 13 (4): 377. doi:10.1016/0376-8716(84)90005-X. PMID 6479016. 
  6. ↑ Wapler, M; Mendelson, J. H.; Teoj, S. K.; Mello, N. K.; Kuehnle, J. C.; Weiss, R. D.; Sholar, S. W.; Hanjra, B et al. (1992). "Buprenorphine attenuates drug craving in men with concurrent heroin and cocaine dependence". Problems of Drug Dependence: 339. 
  7. ↑ Ochoa, Kristen C.; Hahn, Judith A.; Seal, Karen H.; Moss, Andrew R. (2001). "Overdosing among young injection drug users in San Francisco". Addictive Behaviors 26 (3): 453–460. doi:10.1016/S0306-4603(00)00115-5. PMID 11436937. 
  8. ↑ O'Driscoll, Peter T.; McGough, Jim; Hagan, Holly; Thiede, Hanne; Critchlow, Cathy; Alexander, E. Russell (2001). "Predictors of Accidental Fatal Drug Overdose Among a Cohort of Injection Drug Users". American Journal of Public Health 91 (6): 984–987. doi:10.2105/ajph.91.6.984. PMID 11392946. 
  9. ↑ Latkin, Carl A.; Edwards, Catie; Davey-Rothwell, Melissa A.; Yang, Cui; Tobin, Karin E. (2018). "The relationship between drug use settings, roles in the drug economy, and witnessing a drug overdose in Baltimore, Maryland". Substance Abuse 39 (3): 384–389. doi:10.1080/08897077.2018.1439801. PMID 29432084. 
  10. ↑ 10.0 10.1 "2019 National Drug Threat Assessment". Drug Enforcement Administration. 2019. https://www.dea.gov/documents/2020/2020-01/2020-01-30/2019-national-drug-threat-assessment. 
  11. ↑ Rowlett, K.; Negus, S. S.; Shippenberg, T. S.; Mello, N. K.; Walsh, S. L.; Spealman, R. D.. "Combined Cocaine and Opioid Abuse: From Neurobiology to the Clinic". Opioids.com. http://opioids.com/speedballs/. 
  12. ↑ 12.0 12.1 12.2 "Death by Drugs: Fatal Celebrity Drug and Alcohol Addictions". Gatehouse Academy. http://www.gatehouseacademy.com/research/articles/celebrity-drug-and-alcohol-addictions. 
  13. ↑ Largo, Michael (2010). Genius and Heroin: Creativity and Reckless Abandon Through. HarperCollins. p. 22. ISBN 9780062043696. 
  14. ↑ Boyce Davies, Carole (2008). "Basquiat, Jean-Michel (1960-1988)". Encyclopedia of the African Diaspora: Origins, Experiences, and Culture. ABC-CLIO. p. 150. ISBN 978-1-85109-700-5. https://books.google.com/books?id=P9ORpnGJh_IC&q=%22Jean-Michel+Basquiat%22+dead+OR+death+OR+died&pg=PA150. 
  15. ↑ Dowd, Vincent (25 September 2017). "Jean-Michel Basquiat: The neglected genius". BBC News. https://www.bbc.com/news/entertainment-arts-41359913. 
  16. ↑ Litsky, Frank (2 November 2004). "Report Says Overdose Killed Caminiti". The New York Times. https://www.nytimes.com/2004/11/02/sports/baseball/report-says-overdose-killed-caminiti.html. 
  17. ↑ "Chris Farley's Death Laid to Drug Overdose". The New York Times. January 3, 1998. https://www.nytimes.com/1998/01/03/us/chris-farley-s-death-laid-to-drug-overdose.html. 
  18. ↑ Henke, James (26 April 1984). "Chrissie Hynde Without Tears". https://www.rollingstone.com/music/features/chrissie-hynde-without-tears-19840426. 
  19. ↑ Peacock, Tim (1 October 2002). "Obituary: Zac Foley". Whisperin' and Hollerin'. http://www.whisperinandhollerin.com/incoming/item.asp?id=4. 
  20. ↑ "JAG star died from drug overdose, coroner rules". The Sydney Morning Herald. 6 August 2003. http://www.smh.com.au/articles/2003/08/05/1060064185517.html. 
  21. ↑ "Report: Mitch Hedberg died of drug overdose". Today. 27 December 2005. https://www.today.com/popculture/report-mitch-hedberg-died-drug-overdose-1C9482109. 
  22. ↑ "Philip Seymour Hoffman Killed By Massive OD Heroin, Coke, Rx Meds". TMZ. 28 February 2014. http://www.tmz.com/2014/02/28/philip-seymour-hoffman-cause-of-death-heroin-benzodiazepine-amphetamine/. 
  23. ↑ Soltis, Andy (28 February 2014). "Hoffman Died from Toxic Drug Mixture". New York Post. https://nypost.com/2014/02/28/philip-seymour-hoffman-died-from-speedball-drug-mixture/. 
  24. ↑ "UK artist Sebastian Horsley dies of overdose". NineMSN. 18 June 2010. http://news.ninemsn.com.au/article.aspx?id=1072541. 
  25. ↑ Michaels, Sean (8 Aug 2015). "House artist DJ Rashad died of a drug overdose, post-mortem confirms". The Guardian. https://www.theguardian.com/music/2014/aug/08/dj-rashad-died-drug-overdose-autopsy-confirms. 
  26. ↑ Markman, Rob (2 May 2013). "Report: Kris Kross' Chris Kelly Autopsy Complete". MTV. http://www.mtv.com/news/1706734/kris-kross-chris-kelly-autopsy/. 
  27. ↑ "Grateful Dead Member Died of Drug Overdose". Los Angeles Times. 11 August 1990. https://www.latimes.com/archives/la-xpm-1990-08-11-mn-236-story.html. 
  28. ↑ Mydans, Seth (13 November 1993). "Death of River Phoenix Is Linked To Use of Cocaine and Morphine". The New York Times. https://www.nytimes.com/1993/11/13/us/death-of-river-phoenix-is-linked-to-use-of-cocaine-and-morphine.html. 
  29. ↑ Alfonso, Barry (2002). The Billboard Guide to Contemporary Christian Music. Billboard Books. p. 243. ISBN 978-0-8230-7718-2. https://books.google.com/books?id=VzFZZ4yi3DMC&q=%22Judee+Sill%22+dead+OR+death+OR+died&pg=PA243. 
  30. ↑ "Report: Staley Died of Heroin/Cocaine Overdose". 8 May 2002. http://www.billboard.com/articles/news/75852/report-staley-died-of-heroincocaine-overdose. 
  31. ↑ Aldrich, Robert; Wotherspoon, Garry (23 November 2000). Who's Who in Contemporary Gay and Lesbian History Vol.2: From World War II to the Present Day. Routledge. p. 387. ISBN 978-0-203-99408-5. https://books.google.com/books?id=nCpMNSGhXy0C&pg=PA387.  Based on information from Charles Isherwood's Wonder Bread and Ecstasy.
  32. ↑ "Medical Examiner Reveals Cause of Death for Michael K. Williams". 24 September 2021. https://www.thedailybeast.com/the-wire-actor-michael-k-williams-died-due-to-accidental-drug-mixture-nyc-medical-examiner-says. 
  33. ↑ Himmelsbach, Eric (8 July 2004). "Little Drummer Boy Lost". LA CityBeat (Southland Publishing). 
  34. ↑ Davis, Johnny (28 October 2007). "This Much I Know: Dave Gahan, singer, 45, London". The Observer. https://www.theguardian.com/theobserver/2007/oct/28/magazine.features7. 
  35. ↑ Hudson, Saul (2007). Slash. United States: HarperEntertainment. p. 480. ISBN 978-0-06-135142-6. 

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