Chemistry:Uroguanylin

From HandWiki
guanylate cyclase activator 2B (uroguanylin)
Identifiers
SymbolGUCA2B
NCBI gene2981
HGNC4683
OMIM601271
RefSeqNM_007102
UniProtQ16661
Other data
LocusChr. 1 p34-p33
Uroguanylin
Stereo, skeletal formula of uroguanylin
Identifiers
3D model (JSmol)
ChemSpider
MeSH uroguanylin
UNII
Properties
C61H101N17O25S4
Molar mass 1600.81 g·mol−1
Related compounds
Related compounds
PMDTA
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Uroguanylin is a 16 amino acid peptide that is secreted by enterochromaffin cells in the duodenum and proximal small intestine. Guanylin acts as an agonist of the guanylyl cyclase receptor guanylate cyclase 2C (GC-C), and regulates electrolyte and water transport in intestinal and renal epithelia. By agonizing this guanylyl cyclase receptor, uroguanylin and guanylin cause intestinal secretion of chloride and bicarbonate to dramatically increase; this process is helped by the second messenger cGMP.[1] Its sequence is H-Asn-Asp-Asp-Cys(1)-Glu-Leu-Cys(2)-Val-Asn-Val-Ala-Cys(1)-Thr-Gly-Cys(2)-Leu-OH.

In humans, the uroguanylin peptide is encoded by the GUCA2B gene.[2][3] Uroguanylin may be involved in appetite and perceptions of 'fullness' after eating meals, as suggested by a study into mice.[4]

See also

  • Natriuretic peptide
  • Plecanatide – a medication structurally related to uroguanylin

References

  1. Forte, Leonard Ralph (1 November 2004). "Uroguanylin and guanylin peptides: pharmacology and experimental therapeutics". Pharmacology & Therapeutics 104 (2): 137–162. doi:10.1016/j.pharmthera.2004.08.007. PMID 15518884. https://www.sciencedirect.com/science/article/abs/pii/S016372580400124X. Retrieved 16 January 2023. 
  2. "Cloning and characterization of a cDNA encoding a precursor for human uroguanylin". Biochemical and Biophysical Research Communications 219 (2): 644–8. February 1996. doi:10.1006/bbrc.1996.0287. PMID 8605041. 
  3. "Genomic structure and chromosomal localization of human uroguanylin". Genomics 43 (3): 359–65. August 1997. doi:10.1006/geno.1997.4808. PMID 9268639. 
  4. "The uroguanylin system and human disease". Clinical Science 123 (12): 659–68. December 2012. doi:10.1042/CS20120021. PMID 22877138. 

External links