Chemistry:Uroguanylin
guanylate cyclase activator 2B (uroguanylin) | |
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Identifiers | |
Symbol | GUCA2B |
NCBI gene | 2981 |
HGNC | 4683 |
OMIM | 601271 |
RefSeq | NM_007102 |
UniProt | Q16661 |
Other data | |
Locus | Chr. 1 p34-p33 |
Identifiers | |
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3D model (JSmol)
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ChemSpider | |
MeSH | uroguanylin |
PubChem CID
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UNII | |
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Properties | |
C61H101N17O25S4 | |
Molar mass | 1600.81 g·mol−1 |
Related compounds | |
Related compounds
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PMDTA |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
Infobox references | |
Uroguanylin is a 16 amino acid peptide that is secreted by enterochromaffin cells in the duodenum and proximal small intestine. Guanylin acts as an agonist of the guanylyl cyclase receptor guanylate cyclase 2C (GC-C), and regulates electrolyte and water transport in intestinal and renal epithelia. By agonizing this guanylyl cyclase receptor, uroguanylin and guanylin cause intestinal secretion of chloride and bicarbonate to dramatically increase; this process is helped by the second messenger cGMP.[1] Its sequence is H-Asn-Asp-Asp-Cys(1)-Glu-Leu-Cys(2)-Val-Asn-Val-Ala-Cys(1)-Thr-Gly-Cys(2)-Leu-OH.
In humans, the uroguanylin peptide is encoded by the GUCA2B gene.[2][3] Uroguanylin may be involved in appetite and perceptions of 'fullness' after eating meals, as suggested by a study into mice.[4]
See also
- Natriuretic peptide
- Plecanatide – a medication structurally related to uroguanylin
References
- ↑ Forte, Leonard Ralph (1 November 2004). "Uroguanylin and guanylin peptides: pharmacology and experimental therapeutics". Pharmacology & Therapeutics 104 (2): 137–162. doi:10.1016/j.pharmthera.2004.08.007. PMID 15518884. https://www.sciencedirect.com/science/article/abs/pii/S016372580400124X. Retrieved 16 January 2023.
- ↑ "Cloning and characterization of a cDNA encoding a precursor for human uroguanylin". Biochemical and Biophysical Research Communications 219 (2): 644–8. February 1996. doi:10.1006/bbrc.1996.0287. PMID 8605041.
- ↑ "Genomic structure and chromosomal localization of human uroguanylin". Genomics 43 (3): 359–65. August 1997. doi:10.1006/geno.1997.4808. PMID 9268639.
- ↑ "The uroguanylin system and human disease". Clinical Science 123 (12): 659–68. December 2012. doi:10.1042/CS20120021. PMID 22877138.
External links
- uroguanylin at the US National Library of Medicine Medical Subject Headings (MeSH)
Original source: https://en.wikipedia.org/wiki/Uroguanylin.
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