Chemistry:Verosudil

Verosudil
Identifiers
	IUPAC name 2-(dimethylamino)-N-(1-oxo-2H-isoquinolin-6-yl)-2-thiophen-3-ylacetamide;
CAS Number	1414854-42-4;
PubChem CID	66906051;
ChemSpider	32742441;
UNII	MAF34143WM;
KEGG	D10737;
ChEMBL	ChEMBL3545065;
Chemical and physical data
Formula	C17H17N3O2S
Molar mass	327.40 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CN(C)C(C1=CSC=C1)C(=O)NC2=CC3=C(C=C2)C(=O)NC=C3;
	InChI InChI=1S/C17H17N3O2S/c1-20(2)15(12-6-8-23-10-12)17(22)19-13-3-4-14-11(9-13)5-7-18-16(14)21/h3-10,15H,1-2H3,(H,18,21)(H,19,22); Key:VDYRZXYYQMMFJW-UHFFFAOYSA-N;

Short description: Chemical compound

Verosudil (AR-12286) is a drug which acts as a potent and selective inhibitor of the enzyme Rho kinase, and has been investigated for the treatment of glaucoma.^[1]^[2]

References

↑ "Ocular hypotensive effect of the Rho kinase inhibitor AR-12286 in patients with glaucoma and ocular hypertension". American Journal of Ophthalmology 152 (5): 834–41.e1. November 2011. doi:10.1016/j.ajo.2011.04.012. PMID 21794845.
↑ "Efficacy of Topically Administered Rho-Kinase Inhibitor AR-12286 in Patients With Exfoliation Syndrome and Ocular Hypertension or Glaucoma". Journal of Glaucoma 25 (9): e807-14. September 2016. doi:10.1097/IJG.0000000000000508. PMID 27552517.

0.00

(0 votes)

Original source: https://en.wikipedia.org/wiki/Verosudil. Read more

[1] "Ocular hypotensive effect of the Rho kinase inhibitor AR-12286 in patients with glaucoma and ocular hypertension". American Journal of Ophthalmology 152 (5): 834–41.e1. November 2011. doi:10.1016/j.ajo.2011.04.012. PMID 21794845.

[2] "Efficacy of Topically Administered Rho-Kinase Inhibitor AR-12286 in Patients With Exfoliation Syndrome and Ocular Hypertension or Glaucoma". Journal of Glaucoma 25 (9): e807-14. September 2016. doi:10.1097/IJG.0000000000000508. PMID 27552517.

[1]

[2]

Anonymous

Search

Chemistry:Verosudil

Namespaces

More

Page actions

See also

References

Navigation

Navigation

Help

Translate

Wiki tools

Wiki tools

Identifiers

IUPAC name 2-(dimethylamino)-N-(1-oxo-2H-isoquinolin-6-yl)-2-thiophen-3-ylacetamide
CAS Number	1414854-42-4
PubChem CID	66906051
ChemSpider	32742441
UNII	MAF34143WM
KEGG	D10737
ChEMBL	ChEMBL3545065
Chemical and physical data
Formula	C₁₇H₁₇N₃O₂S
Molar mass	327.40 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CN(C)C(C1=CSC=C1)C(=O)NC2=CC3=C(C=C2)C(=O)NC=C3
InChI InChI=1S/C17H17N3O2S/c1-20(2)15(12-6-8-23-10-12)17(22)19-13-3-4-14-11(9-13)5-7-18-16(14)21/h3-10,15H,1-2H3,(H,18,21)(H,19,22) Key:VDYRZXYYQMMFJW-UHFFFAOYSA-N

Anonymous

Search

Chemistry:Verosudil

See also

References

Navigation

Wiki tools

Page tools

Other projects

Categories