Medicine:Polyostotic fibrous dysplasia

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Polyostotic fibrous dysplasia
Other namesAlbright's disease[1]:578
SpecialtyOsteology

Polyostotic fibrous dysplasia is a form of fibrous dysplasia affecting more than one bone.[2] Fibrous dysplasia is a disorder where bone is replaced by fibrous tissue, leading to weak bones, uneven growth, and deformity. [3]

McCune-Albright syndrome includes polyostotic fibrous dysplasia as part of its presentation.[4] When polyostotic fibrous dysplasia manifests in the long bones, limping results; when it manifests in the face, asymmetric growth of the face can result.[3]

One treatment that has been used is bisphosphonates.[5]

See also

References

  1. James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. ISBN:0-7216-2921-0.
  2. "Fibrous Dysplasia: Overview - eMedicine Radiology". http://emedicine.medscape.com/article/389714-overview. 
  3. 3.0 3.1 Reference, Genetics Home. "McCune-Albright syndrome" (in en). https://ghr.nlm.nih.gov/condition/mccune-albright-syndrome. 
  4. Lee, Peter A. (5 December 1986). "McCune-Albright Syndrome: Long-term Follow-up". JAMA: The Journal of the American Medical Association 256 (21): 2980–4. doi:10.1001/jama.1986.03380210076028. PMID 3773215. 
  5. "Oral bisphosphonates in polyostotic fibrous dysplasia". Indian Pediatr 40 (9): 894–6. September 2003. PMID 14530553. http://www.indianpediatrics.net/sep2003/sep-894-896.htm. 

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