Medicine:Janeway lesion
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Janeway lesions are non-tender, small erythematous or haemorrhagic macular or nodular lesions on the palms or soles only a few millimeters in diameter that are indicative of infective endocarditis.[1]
Osler's nodes and Janeway lesions are similar, but Osler's nodes present with tenderness and are of immunologic origin.[2]
Causes
Pathologically, the lesion is described to be a microabscess of the dermis with marked necrosis and inflammatory infiltrate not involving the epidermis.[1] They are caused by septic emboli which deposit bacteria, forming microabscesses.[3] Janeway lesions are distal, flat, ecchymotic, and painless.
Diagnosis
Etymology
Janeway lesions are named after Edward Janeway (1841–1911), a prominent American physician and pathologist who initially described the lesions.
See also
- Roth's spots
- Osler's node
References
- ↑ 1.0 1.1 Farrior, J.B.; Silverman M.E. (1976). "A consideration of the differences between a Janeway's lesion and an Osler's node in infectious endocarditis". Chest 70 (2): 239–243. doi:10.1378/chest.70.2.239. PMID 947688.
- ↑ "A consideration of the differences between a Janeway's lesion and an Osler's node in infectious endocarditis". Chest 70 (2): 239–243. August 1976. doi:10.1378/chest.70.2.239. PMID 947688. http://www.chestjournal.org/cgi/pmidlookup?view=long&pmid=947688.
- ↑ Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases, 7th ed., Churchill Livingstone 2009.
External links
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