Biology:Karyorrhexis
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Short description: Destructive fragmentation of the nucleus of a dying cell
Karyorrhexis (from Greek κάρυον karyon 'kernel, seed, nucleus' and ῥῆξις rhexis 'bursting') is the destructive fragmentation of the nucleus of a dying cell[1] whereby its chromatin is distributed irregularly throughout the cytoplasm.[2] It is usually preceded by pyknosis and can occur as a result of either programmed cell death (apoptosis), cellular senescence, or necrosis.
In apoptosis, the cleavage of DNA is done by Ca2+ and Mg2+ -dependent endonucleases.
Morphological characteristics of pyknosis and other forms of nuclear destruction.
Microscopy of an apoptotic neutrophil with nuclear fragmentation (H&E stain)
See also
References
- ↑ "Apoptosis: Condensed matter in cell death". Nature 401 (127): 127–8. 1999. doi:10.1038/43591. PMID 10490018. Bibcode: 1999Natur.401..127Z.
- ↑ (in en) Advances in Mutagenesis Research. Springer Science & Business Media. 2012. p. 11. ISBN 9783642781933. https://books.google.com/books?id=uyDsCAAAQBAJ&q=Karyorrhexis. Retrieved 11 November 2017.
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