Chemistry:SR-17018
From HandWiki
Short description: Chemical compound
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| Formula | C19H18Cl3N3O |
| Molar mass | 410.72 g·mol−1 |
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SR-17018 is a drug which acts as a biased agonist at the μ-opioid receptor, selective for activation of the G-protein signalling pathway over β-arrestin 2 recruitment.[1] In animal studies it produces analgesic effects but with less respiratory depression and development of tolerance than conventional opioids.[2][3][4][5]
See also
References
- ↑ "Molecular recognition of morphine and fentanyl by the human μ-opioid receptor". Cell 185 (23): 4361–4375.e19. November 2022. doi:10.1016/j.cell.2022.09.041. PMID 36368306.
- ↑ "A G protein signaling-biased agonist at the μ-opioid receptor reverses morphine tolerance while preventing morphine withdrawal". Neuropsychopharmacology 45 (2): 416–425. January 2020. doi:10.1038/s41386-019-0491-8. PMID 31443104.
- ↑ "Biased versus Partial Agonism in the Search for Safer Opioid Analgesics". Molecules 25 (17): 3870. August 2020. doi:10.3390/molecules25173870. PMID 32854452.
- ↑ "Molecular Modeling of µ Opioid Receptor Ligands with Various Functional Properties: PZM21, SR-17018, Morphine, and Fentanyl-Simulated Interaction Patterns Confronted with Experimental Data". Molecules 25 (20): 4636. October 2020. doi:10.3390/molecules25204636. PMID 33053718.
- ↑ "Comparison of morphine, oxycodone and the biased MOR agonist SR-17018 for tolerance and efficacy in mouse models of pain". Neuropharmacology 185: 108439. December 2020. doi:10.1016/j.neuropharm.2020.108439. PMID 33345829.
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