Chemistry:TRV734

From HandWiki
Short description: Chemical compound
TRV734
TRV734.svg
Identifiers
PubChem CID
Chemical and physical data
FormulaC22H28FN3O
Molar mass369.484 g·mol−1
3D model (JSmol)

TRV734 is a drug developed by Trevena Inc which acts as a biased agonist at the μ-opioid receptor, selective for activation of the G-protein signalling pathway over β-arrestin 2 recruitment. It is closely related to oliceridine and has a similar pharmacological profile, but unlike oliceridine which has to be injected, TRV734 is suitable to be administered orally.[1]

See also

References

  1. "A First-in-Human Clinical Study With TRV734, an Orally Bioavailable G-Protein-Biased Ligand at the μ-Opioid Receptor". Clinical Pharmacology in Drug Development 9 (2): 256–266. February 2020. doi:10.1002/cpdd.721. PMID 31286645.