Biography:Petra Fromme

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Short description: German-American chemist
Petra Fromme
Petra Fromme at Arizona State University Research.jpg
Fromme in 2017
Alma materTechnical University of Berlin
Free University of Berlin
Scientific career
InstitutionsArizona State University
Max Volmer Institute
ThesisDie ATP-Synthase aus Chloroplasten biochemische Untersuchungen zur Struktur und kinetische Messungen zum Mechanismus des Enzyms (1988)

Petra Fromme is a German-American chemist who is Director of the Biodesign Center for Applied Structural Discovery and Regents Professor at the Arizona State University. Her research considers the structure-to-function relationship of the membrane proteins involved with infectious diseases and bio-energy conversion. In 2021, she was awarded the Protein Society Anfinsen Award.

Early life and education

Fromme was born in Germany . She attended the Free University of Berlin for undergraduate studies, where she majored in biochemistry.[1] She moved to the Technical University of Berlin for her doctoral research, where she investigated the ATP synthase of chloroplasts.[2]

Research and career

Fromme's academic career started at the Max Volmer Institute, part of the Technical University of Berlin.[citation needed] Fromme joined Arizona State University as a Professor of Molecular Sciences in 2002.[3] She was named Paul V Galvin Professor in 2012. In 2014, Fromme was appointed Director of the Centre for Applied Structural Discovery.[4][5] The following year she was selected as a Regents' Professor.[6] At Arizona State, she oversaw the development of two compact X-ray accelerator systems, including an X-ray light source[7] and an X-ray Free Electron Laser.[8][9][10]

Fromme was amongst the first people to use high energy X-ray free-electron lasers to analyze proteins. These lasers, which produce extremely bright and ultra-short pulses of light, allow for serial femtosecond nanocrystallography.[11] Whilst conventional high intensity X-ray pulses can damage the molecules they are interrogating, femtosecond pulses can permit the acquisition of diffraction patterns before the sample degrades.[8] Femtosecond measurements allowed Fromme to establish the structure-property relationships of crucial biological systems, including ATP synthase, Photosystem I and Photosystem II.[12][13][14][15] Nanocrystallography will allow for the development of more safe and effective drugs,[16][17][18] as well as accelerating our understanding of material design for renewable energy sources.[8][19]

In an effort to design new drugs, Fromme has studied the structure of disease-linked enzymes in the human body including Taspase I.[20] The protease is involved with cell metabolism, proliferation, migration and termination, and its dysregulation is implicated in the genesis of various cancers.[21] By investigating Taspase I with free-electron lasers, Fromme showed that there is a critical helical region which defines the protease activity, and eliminating this region can deactiviate the enzyome entirely.[21] X-ray Free Electron Lasers also allowed for the characterisations of Francisella tularensis, the bacterium which gives rise to Tularemia.[22]

She also has published and co published many scientific papers in many journals, like; Three-Dimensional structure of Cyanobacterial photosystem I at 2.5 Å resolution, Crystal Structure of photosystem II from Synechococcus elongatus at 3.8 Å resolution, Femtosecond X-ray protein nano-crystallography, Single mimivirus particulars intercepted and imaged with an X-Ray Laser, and so much more.[23]

Awards and honors

  • 2013 Science Top 10 Breakthrough of the Year[24]
  • 2015 Phoenix New Times Best of Phoenix Award[25]
  • 2021 Fromme was awarded the Protein Society Anfinsen Award[8]

Selected publications

Books

References

  1. ↑ "Petra Fromme" (in en). https://asu.pure.elsevier.com/en/persons/petra-fromme. 
  2. ↑ Fromme, Petra (1988). Die ATP-Synthase aus Chloroplasten biochemische Untersuchungen zur Struktur und kinetische Messungen zum Mechanismus des Enzyms (Thesis) (in German). OCLC 721655618.CS1 maint: unrecognized language (link)
  3. ↑ Ryman, Anne. "New ASU center to expand cutting-edge research" (in en-US). https://www.azcentral.com/story/news/local/tempe/2014/08/01/new-asu-center-expand-cutting-edge-research/13450159/. 
  4. ↑ "ASU protein pioneer honored as innovator at governor's celebration" (in en). https://biodesign.asu.edu/news/asu-protein-pioneer-honored-innovator-governor%E2%80%99s-celebration. 
  5. ↑ "ASU appoints Petra Fromme as director of new Center for Applied Structural Discovery" (in en). https://biodesign.asu.edu/news/asu-appoints-petra-fromme-director-new-center-applied-structural-discovery. 
  6. ↑ "Three ASU faculty members appointed Regents' Professors" (in en). https://biodesign.asu.edu/news/three-asu-faculty-members-appointed-regents-professors. 
  7. ↑ "Beuses' $10 million gift to build world's first-of-its-kind X-ray laser lab at ASU" (in en). https://biodesign.asu.edu/news/beuses-10-million-gift-build-world%E2%80%99s-first-its-kind-x-ray-laser-lab-asu. 
  8. ↑ 8.0 8.1 8.2 8.3 "Petra Fromme honored with the prestigious Anfinsen Award" (in en). https://www.eurekalert.org/news-releases/537659. 
  9. ↑ "The sounds of science: A quiet home for a powerful laser" (in en). https://biodesign.asu.edu/news/sounds-science-quiet-home-powerful-laser. 
  10. ↑ "Bright lights, big science: Revolutionary laser instrument receives $4.7 million boost from the National Science Foundation" (in en). https://biodesign.asu.edu/news/bright-lights-big-science-revolutionary-laser-instrument-receives-47-million-boost-national. 
  11. ↑ "Time-resolved Femtosecond Crystallography: Toward Molecular Movies of Molecules In Action" (in en). https://biodesign.asu.edu/news/time-resolved-femtosecond-crystallography-toward-molecular-movies-molecules-action. 
  12. ↑ "Petra Fromme" (in en). https://biodesign.asu.edu/petra-fromme. 
  13. ↑ "BioXFEL - Petra Fromme". https://www.bioxfel.org/people/fromme. 
  14. ↑ "Photosynthesis seen in a new light by rapid X-ray pulses" (in en). https://biodesign.asu.edu/news/photosynthesis-seen-new-light-rapid-x-ray-pulses. 
  15. ↑ "X-ray study unlocks secrets of light-sensing organism" (in en). https://biodesign.asu.edu/news/x-ray-study-unlocks-secrets-light-sensing-organism. 
  16. ↑ "Research team finds possible new approach for sleeping sickness drugs" (in en). https://biodesign.asu.edu/news/research-team-finds-possible-new-approach-sleeping-sickness-drugs. 
  17. ↑ "One step closer: Membrane protein structure expressed in Lyme disease could offer therapeutic target" (in en). https://biodesign.asu.edu/news/one-step-closer-membrane-protein-structure-expressed-lyme-disease-could-offer-therapeutic. 
  18. ↑ "X-ray pulses reveal structure of viral cocoon" (in en). https://biodesign.asu.edu/news/x-ray-pulses-reveal-structure-viral-cocoon. 
  19. ↑ "Research" (in en). https://biodesign.asu.edu/petra-fromme/research. 
  20. ↑ "Finding answers to cancer in the cosmos" (in en). https://biodesign.asu.edu/news/finding-answers-cancer-cosmos. 
  21. ↑ 21.0 21.1 "First detailed look at crucial enzyme advances cancer research" (in en). https://biodesign.asu.edu/news/first-detailed-look-crucial-enzyme-advances-cancer-research. 
  22. ↑ "X-ray eyes peer deeper into deadly pathogen" (in en). https://biodesign.asu.edu/news/x-ray-eyes-peer-deeper-deadly-pathogen. 
  23. ↑ "Petra Fromme". https://scholar.google.com/citations?user=rRHlYT0AAAAJ&hl=en. 
  24. ↑ "ASU research makes Science's top 10 breakthroughs" (in en). 2013-01-13. https://news.asu.edu/content/asu-research-makes-sciences-top-10-breakthroughs. 
  25. ↑ "Fromme garners Best of Phoenix award" (in en). https://biodesign.asu.edu/news/fromme-garners-best-phoenix-award. 





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