Biology:Gamma-glutamyl hydrolase
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
Ghk.
| Gamma-glutamyl hydrolase | |||||||||
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| Identifiers | |||||||||
| EC number | 3.4.19.9 | ||||||||
| CAS number | 9074-87-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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 Generic protein structure example |
Gamma-glutamyl hydrolase is an enzyme[1][2][3][4] that catalyses the following chemical reaction:
- Hydrolysis of a gamma-glutamyl bond
This lysosomal or secreted, thiol-dependent peptidase, most active at acidic pH.
In humans, gamma-glutamyl hydrolase is encoded by the GGH gene.[3][5][6] This gene catalyzes the hydrolysis of folylpoly-gamma-glutamates and antifolylpoly-gamma-glutamates by the removal of gamma-linked polyglutamates and glutamate.[6]
Nomenclature
Gamma-glutamyl hydrolase is also known as conjugase, folate conjugase, lysosomal gamma-glutamyl carboxypeptidase, gamma-Glu-X carboxypeptidase, pteroyl-poly-gamma-glutamate hydrolase, carboxypeptidase G, folic acid conjugase, poly(gamma-glutamic acid) endohydrolase, polyglutamate hydrolase, poly(glutamic acid) hydrolase II, pteroylpoly-gamma-glutamyl hydrolase.
Interactive pathway map
References
- ↑ "The properties of the secreted gamma-glutamyl hydrolases from H35 hepatoma cells". Biochim. Biophys. Acta 1164 (3): 227–35. August 1993. doi:10.1016/0167-4838(93)90253-n. PMID 8343522.
- ↑ "Effects of gamma-glutamyl hydrolase on folyl and antifolylpolyglutamates in cultured H35 hepatoma cells". Mol. Pharmacol. 48 (3): 505–11. September 1995. PMID 7565632.
- ↑ 3.0 3.1 "Human gamma-glutamyl hydrolase: cloning and characterization of the enzyme expressed in vitro". Proc. Natl. Acad. Sci. U.S.A. 93 (19): 10134–8. September 1996. doi:10.1073/pnas.93.19.10134. PMID 8816764. Bibcode: 1996PNAS...9310134Y.
- ↑ "Identification, cloning, and sequencing of a cDNA coding for rat gamma-glutamyl hydrolase". J. Biol. Chem. 271 (15): 8525–8. April 1996. doi:10.1074/jbc.271.15.8525. PMID 8621474.
- ↑ "Structural organization of the human gamma-glutamyl hydrolase gene". Gene 238 (2): 463–70. Dec 1999. doi:10.1016/S0378-1119(99)00362-5. PMID 10570974.
- ↑ 6.0 6.1 "Entrez Gene: GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8836.
Further reading
- "Glutamyl hydrolase: properties and pharmacologic impact". Semin. Oncol. 26 (2 Suppl 6): 33–7. 1999. PMID 10598552.
- "Secretion of gamma-glutamyl hydrolase in vitro". Cancer Res. 51 (15): 3874–81. 1991. PMID 1713122.
- "Pteroylpolyglutamate hydrolase from human jejunal brush borders. Purification and characterization". J. Biol. Chem. 261 (2): 928–33. 1986. doi:10.1016/S0021-9258(17)36185-9. PMID 2867095.
- "Intracellular pteroylpolyglutamate hydrolase from human jejunal mucosa. Isolation and characterization". J. Biol. Chem. 261 (29): 13551–5. 1986. doi:10.1016/S0021-9258(18)67054-1. PMID 3759978.
- "Identification, cloning, and sequencing of a cDNA coding for rat gamma-glutamyl hydrolase". J. Biol. Chem. 271 (15): 8525–8. 1996. doi:10.1074/jbc.271.15.8525. PMID 8621474.
- "Characterization of human cellular gamma-glutamyl hydrolase". Mol. Pharmacol. 53 (6): 1040–6. 1998. PMID 9614206.
- "Three-dimensional structure of human gamma -glutamyl hydrolase. A class I glatamine amidotransferase adapted for a complex substate". J. Biol. Chem. 277 (27): 24522–9. 2002. doi:10.1074/jbc.M202020200. PMID 11953431.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Proteomic analysis of early melanosomes: identification of novel melanosomal proteins". J. Proteome Res. 2 (1): 69–79. 2003. doi:10.1021/pr025562r. PMID 12643545.
- "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Identification of carboxypeptidase E and gamma-glutamyl hydrolase as biomarkers for pulmonary neuroendocrine tumors by cDNA microarray". Hum. Pathol. 35 (10): 1196–209. 2004. doi:10.1016/j.humpath.2004.06.014. PMID 15492986. https://zenodo.org/record/1259009. Retrieved 2020-09-10.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "Characterization of Human gamma-glutamyl hydrolase in solution demonstrates that the enzyme is a non-dissociating homodimer". Biochim. Biophys. Acta 1764 (9): 1479–86. 2006. doi:10.1016/j.bbapap.2006.06.008. PMID 16945597.
- "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes". J. Proteome Res. 5 (11): 3135–44. 2007. doi:10.1021/pr060363j. PMID 17081065.
- "Genetic polymorphism of C452T (T127I) in human gamma-glutamyl hydrolase in a Japanese population". Biol. Pharm. Bull. 30 (4): 839–41. 2007. doi:10.1248/bpb.30.839. PMID 17409534.
External links
- Gamma-glutamyl+hydrolase at the US National Library of Medicine Medical Subject Headings (MeSH)
- Overview of all the structural information available in the PDB for UniProt: Q92820 (Gamma-glutamyl hydrolase) at the PDBe-KB.
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