Biology:Beta-amyrin synthase
From HandWiki
| β-Amyrin synthase | |||||||||
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| Identifiers | |||||||||
| EC number | 5.4.99.39 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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β-amyrin synthase (EC 5.4.99.39, 2,3-oxidosqualene beta-amyrin cyclase, AsbAS1, BPY, EtAS, GgbAS1, LjAMY1, MtAMY1, PNY, BgbAS) is an enzyme with systematic name (3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, beta-amyrin-forming).[1][2][3][4][5][6][7][8][9][10][11] This enzyme catalyses the following chemical reaction
- (3S)-2,3-epoxy-2,3-dihydrosqualene [math]\displaystyle{ \rightleftharpoons }[/math] beta-amyrin
Some organism possess a monofunctional beta-amyrin synthase.
References
- ↑ "Purification of squalene-2,3-epoxide cyclases from cell suspension cultures of Rabdosia japonica Hara". FEBS Lett. 249: 100–104. 1989. doi:10.1016/0014-5793(89)80024-9.
- ↑ "Purification of 2,3-oxdosqualene:β-amyrin cyclase from pea seedlings". Chem. Pharm. Bull. 37: 536–. 1989. doi:10.1248/cpb.37.536.
- ↑ "Beta-amyrin synthase--cloning of oxidosqualene cyclase that catalyzes the formation of the most popular triterpene among higher plants". European Journal of Biochemistry 256 (1): 238–44. August 1998. doi:10.1046/j.1432-1327.1998.2560238.x. PMID 9746369.
- ↑ "Cloning and characterization of a cDNA encoding beta-amyrin synthase involved in glycyrrhizin and soyasaponin biosyntheses in licorice". Biological & Pharmaceutical Bulletin 24 (8): 912–6. August 2001. doi:10.1248/bpb.24.912. PMID 11510484.
- ↑ "Molecular cloning and expression in yeast of 2,3-oxidosqualene-triterpenoid cyclases from Arabidopsis thaliana". Plant Molecular Biology 45 (1): 75–92. January 2001. doi:10.1023/A:1006476123930. PMID 11247608.
- ↑ "Molecular cloning and characterization of triterpene synthases from Medicago truncatula and Lotus japonicus". Plant Molecular Biology 51 (5): 731–43. March 2003. doi:10.1023/a:1022519709298. PMID 12683345.
- ↑ "Oxidosqualene cyclases from cell suspension cultures of Betula platyphylla var. japonica: molecular evolution of oxidosqualene cyclases in higher plants". Biological & Pharmaceutical Bulletin 26 (5): 642–50. May 2003. doi:10.1248/bpb.26.642. PMID 12736505.
- ↑ "Differential expression of three oxidosqualene cyclase mRNAs in Glycyrrhiza glabra". Biological & Pharmaceutical Bulletin 27 (7): 1086–92. July 2004. doi:10.1248/bpb.27.1086. PMID 15256745.
- ↑ "Cloning and characterization of a cDNA encoding beta-amyrin synthase from petroleum plant Euphorbia tirucalli L". Phytochemistry 66 (15): 1759–66. August 2005. doi:10.1016/j.phytochem.2005.05.021. PMID 16005035.
- ↑ "Triterpene synthases from the Okinawan mangrove tribe, Rhizophoraceae". The FEBS Journal 274 (19): 5028–42. October 2007. doi:10.1111/j.1742-4658.2007.06025.x. PMID 17803686.
- ↑ "Cloning and Functional Analysis of a beta-amyrin synthase gene associated with oleanolic acid biosynthesis in Gentiana straminea MAXIM". Biological & Pharmaceutical Bulletin 32 (5): 818–24. May 2009. doi:10.1248/bpb.32.818. PMID 19420748.
External links
- Beta-amyrin+synthase at the US National Library of Medicine Medical Subject Headings (MeSH)
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