Biology:4-hydroxybenzoyl-CoA reductase
From HandWiki
| 4-hydroxybenzoyl-CoA reductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.3.7.9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a 4-hydroxybenzoyl-CoA reductase (EC 1.3.7.9) is an enzyme found in some bacteria and archaea that catalyzes the chemical reaction[1][2]
- benzoyl-CoA + acceptor + H2O [math]\displaystyle{ \rightleftharpoons }[/math] 4-hydroxybenzoyl-CoA + reduced acceptor
The 3 substrates of this enzyme are benzoyl-CoA, acceptor, and H2O, whereas its two products are 4-hydroxybenzoyl-CoA and reduced acceptor.
This enzyme participates in benzoate degradation via coa ligation.
Nomenclature
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with other acceptors. The systematic name of this enzyme class is benzoyl-CoA:acceptor oxidoreductase. Other names in common use include:
- 4-hydroxybenzoyl-CoA reductase (dehydroxylating), and
- 4-hydroxybenzoyl-CoA:(acceptor) oxidoreductase.
References
- ↑ "Reductive dehydroxylation of 4-hydroxybenzoyl-CoA to benzoyl-CoA in a denitrifying, phenol-degrading Pseudomonas species". FEBS Lett. 251 (1–2): 237–40. 1989. doi:10.1016/0014-5793(89)81461-9. PMID 2753161.
- ↑ "Differential induction of enzymes involved in anaerobic metabolism of aromatic compounds in the denitrifying bacterium Thauera aromatica". Arch. Microbiol. 170 (2): 120–31. August 1998. doi:10.1007/s002030050623. PMID 9683649.
Further reading
- "4-Hydroxybenzoyl-CoA reductase (dehydroxylating) from the denitrifying bacterium Thauera aromatica--prosthetic groups, electron donor, and genes of a member of the molybdenum-flavin-iron-sulfur proteins". Eur. J. Biochem. 251 (3): 916–23. 1998. doi:10.1046/j.1432-1327.1998.2510916.x. PMID 9490068.
- "Enzymes of anaerobic metabolism of phenolic compounds 4-Hydroxybenzoyl-CoA reductase (dehydroxylating) from a denitrifying Pseudomonas species". Eur. J. Biochem. 213 (1): 563–71. 1993. doi:10.1111/j.1432-1033.1993.tb17795.x. PMID 8477729.
- "Anaerobic metabolism of aromatic compounds". Eur. J. Biochem. 243 (3): 577–96. 1997. doi:10.1111/j.1432-1033.1997.00577.x. PMID 9057820. http://www.as.ysu.edu/~crcooper/aromatic%20review.pdf.
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