Biology:2-Coumarate reductase
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Short description: Class of enzymes
2-coumarate reductase | |||||||||
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Identifiers | |||||||||
EC number | 1.3.1.11 | ||||||||
CAS number | 37251-10-8 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a 2-coumarate reductase or melilotate dehydrogenase (EC 1.3.1.11) is an enzyme that catalyzes the chemical reaction
- 3-(2-hydroxyphenyl)propanoate + NAD+ [math]\displaystyle{ \rightleftharpoons }[/math] 2-coumarate + NADH + H+
Thus, the two substrates of this enzyme are 3-(2-hydroxyphenyl)propanoate and NAD+, whereas its 3 products are 2-coumarate, NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 3-(2-hydroxyphenyl)propanoate:NAD+ oxidoreductase. This enzyme participates in phenylalanine metabolism.
References
- "The metabolism of coumarin by a microorganism. II. The reduction of o-coumaric acid to melilotic acid". Biochemistry 3 (12): 1944–7. December 1964. doi:10.1021/bi00900a027. PMID 14269315.
![]() | Original source: https://en.wikipedia.org/wiki/2-Coumarate reductase.
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