Biology:RABEP1

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Rab GTPase-binding effector protein 1 is an enzyme that in humans is encoded by the RABEP1 gene. It belongs to rabaptin protein family.

Interactions

RABEP1 has been shown to interact with:

• AP1G1,
• GGA1,
• GGA2,
• RAB4A, and
• RAB5A.

Further reading

• "The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis". The Journal of Biological Chemistry 272 (10): 6097–100. Mar 1997. doi:10.1074/jbc.272.10.6097. PMID 9045618. 
• "Distinct Rab-binding domains mediate the interaction of Rabaptin-5 with GTP-bound Rab4 and Rab5". The EMBO Journal 17 (7): 1941–51. Apr 1998. doi:10.1093/emboj/17.7.1941. PMID 9524117. 
• "The neuronal growth-associated protein GAP-43 interacts with rabaptin-5 and participates in endocytosis". The Journal of Neuroscience 18 (19): 7757–67. Oct 1998. doi:10.1523/JNEUROSCI.18-19-07757.1998. PMID 9742146. 
• "Human rabaptin-5 is selectively cleaved by caspase-3 during apoptosis". The Journal of Biological Chemistry 274 (53): 37583–90. Dec 1999. doi:10.1074/jbc.274.53.37583. PMID 10608812. 
• "Rabaptin4, a novel effector of the small GTPase rab4a, is recruited to perinuclear recycling vesicles". The Biochemical Journal 346 (3): 593–601. Mar 2000. doi:10.1042/0264-6021:3460593. PMID 10698684. 
• "A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome". The Journal of Cell Biology 149 (1): 67–80. Apr 2000. doi:10.1083/jcb.149.1.67. PMID 10747088. 
• "The MAK-V protein kinase regulates endocytosis in mouse". Molecular & General Genetics 264 (4): 411–8. Nov 2000. doi:10.1007/s004380000293. PMID 11129044. 
• "Binding of GGA2 to the lysosomal enzyme sorting motif of the mannose 6-phosphate receptor". Science 292 (5522): 1716–8. Jun 2001. doi:10.1126/science.1060896. PMID 11387476. Bibcode: 2001Sci...292.1716Z. 
• "Identification of rabaptin-5, rabex-5, and GM130 as putative effectors of rab33b, a regulator of retrograde traffic between the Golgi apparatus and ER". FEBS Letters 508 (2): 201–9. Nov 2001. doi:10.1016/S0014-5793(01)02993-3. PMID 11718716. 
• "Divalent Rab effectors regulate the sub-compartmental organization and sorting of early endosomes". Nature Cell Biology 4 (2): 124–33. Feb 2002. doi:10.1038/ncb744. PMID 11788822. 
• "Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex". The EMBO Journal 22 (1): 78–88. Jan 2003. doi:10.1093/emboj/cdg015. PMID 12505986. 
• "The trihelical bundle subdomain of the GGA proteins interacts with multiple partners through overlapping but distinct sites". The Journal of Biological Chemistry 279 (30): 31409–18. Jul 2004. doi:10.1074/jbc.M402183200. PMID 15143060. 
• "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Current Biology 14 (16): 1436–50. Aug 2004. doi:10.1016/j.cub.2004.07.051. PMID 15324660. 
• "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research 16 (1): 55–65. Jan 2006. doi:10.1101/gr.4039406. PMID 16344560. 
• "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology 3 (1): 89. 2007. doi:10.1038/msb4100134. PMID 17353931.