Biology:GLUD2
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Short description: Protein-coding gene in humans
 Generic protein structure example |
Glutamate dehydrogenase 2, mitochondrial, also known as GDH 2, is an enzyme that in humans is encoded by the GLUD2 gene.[1][2][3] This dehydrogenase is one of the family of glutamate dehydrogenases that are ubiquitous in life.
Function
Glutamate dehydrogenase 2 is localized to the mitochondrion and acts as a homohexamer to recycle glutamate during neurotransmission. The encoded enzyme catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate.[1]
References
- ↑ 1.0 1.1 "Entrez Gene: glutamate dehydrogenase 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2747.
- ↑ "Novel human glutamate dehydrogenase expressed in neural and testicular tissues and encoded by an X-linked intronless gene". J. Biol. Chem. 269 (24): 16971–6. June 1994. doi:10.1016/S0021-9258(19)89484-X. PMID 8207021.
- ↑ "Nerve tissue-specific human glutamate dehydrogenase that is thermolabile and highly regulated by ADP". J. Neurochem. 68 (5): 1804–11. May 1997. doi:10.1046/j.1471-4159.1997.68051804.x. PMID 9109504.
Further reading
- "The DNA sequence of the human X chromosome". Nature 434 (7031): 325–37. 2005. doi:10.1038/nature03440. PMID 15772651. Bibcode: 2005Natur.434..325R.
- "Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis". Eur. J. Hum. Genet. 17 (7): 946–57. 2009. doi:10.1038/ejhg.2008.264. PMID 19156168.
- "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–68. 2005. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
- "Birth and adaptive evolution of a hominoid gene that supports high neurotransmitter flux". Nat. Genet. 36 (10): 1061–3. 2004. doi:10.1038/ng1431. PMID 15378063.
- "Gain-of-function variant in GLUD2 glutamate dehydrogenase modifies Parkinson's disease onset". Eur. J. Hum. Genet. 18 (3): 336–41. 2010. doi:10.1038/ejhg.2009.179. PMID 19826450.
- "Critical role of the cysteine 323 residue in the catalytic activity of human glutamate dehydrogenase isozymes". Mol. Cells 19 (1): 97–103. 2005. doi:10.1016/S1016-8478(23)13142-6. PMID 15750346.
- "Important role of Ser443 in different thermal stability of human glutamate dehydrogenase isozymes". FEBS Lett. 562 (1–3): 59–64. 2004. doi:10.1016/S0014-5793(04)00183-8. PMID 15044002.
- "Mutations in human GLUD2 glutamate dehydrogenase affecting basal activity and regulation". J. Neurochem. 109 (Suppl 1): 167–73. 2009. doi:10.1111/j.1471-4159.2009.05914.x. PMID 19393024.
- "Molecular basis of human glutamate dehydrogenase regulation under changing energy demands". J. Neurosci. Res. 79 (1–2): 65–73. 2005. doi:10.1002/jnr.20353. PMID 15578726.
- "The structure of apo human glutamate dehydrogenase details subunit communication and allostery". J. Mol. Biol. 318 (3): 765–77. 2002. doi:10.1016/S0022-2836(02)00161-4. PMID 12054821.
- "Study of structure-function relationships in human glutamate dehydrogenases reveals novel molecular mechanisms for the regulation of the nerve tissue-specific (GLUD2) isoenzyme". Neurochem. Int. 43 (4–5): 401–10. 2003. doi:10.1016/S0197-0186(03)00028-7. PMID 12742085.
- "Human GLUD1 and GLUD2 glutamate dehydrogenase localize to mitochondria and endoplasmic reticulum". Biochem. Cell Biol. 87 (3): 505–16. 2009. doi:10.1139/o09-008. PMID 19448744.
- "Human GLUD2 glutamate dehydrogenase is expressed in neural and testicular supporting cells". J. Biol. Chem. 285 (22): 16748–56. 2010. doi:10.1074/jbc.M109.092999. PMID 20194501.
- "Protein profiling of human pancreatic islets by two-dimensional gel electrophoresis and mass spectrometry". J. Proteome Res. 4 (3): 931–40. 2005. doi:10.1021/pr050024a. PMID 15952740.
- "Mitochondrial targeting adaptation of the hominoid-specific glutamate dehydrogenase driven by positive Darwinian selection". PLOS Genet. 4 (8): e1000150. 2008. doi:10.1371/journal.pgen.1000150. PMID 18688271.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "The human GLUD2 glutamate dehydrogenase: localization and functional aspects". Neurochem. Int. 55 (1–3): 52–63. 2009. doi:10.1016/j.neuint.2009.03.001. PMID 19428807.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2002. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Properties and molecular evolution of human GLUD2 (neural and testicular tissue-specific) glutamate dehydrogenase". J. Neurosci. Res. 85 (15): 3398–406. 2007. doi:10.1002/jnr.21576. PMID 17924438.
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