Biology:Pseudomon-1 RNA motif
| Pseudomon-1 RNA | |
|---|---|
 Consensus secondary structure of Pseudomon-1 RNAs | |
| Identifiers | |
| Symbol | Pseudomon-1 |
| Rfam | RF01719 |
| Other data | |
| RNA type | sRNA |
| Domain(s) | Pseudomonas |
| PDB structures | PDBe |
The Pseudomon-1 RNA motif is a conserved RNA identified by bioinformatics.[1] It is used by most species whose genomes have been sequenced and that are classified within the genus Pseudomonas, and is also present in Azotobacter vinelandii, a closely related species. It is presumed to function as a non-coding RNA. Pseudomon-1 RNAs consistently have a downstream rho-independent transcription terminator.
The intergenic region containing Pseudomon-1 RNAs were also detected later by an independent study based on deep sequencing and called SPA0122[2] The genes surrounding this region suggest a similarity to Spot 42 RNA,[2] but the Pseudomonas RNA functions to regulate the AlgC enzyme[3] Based on this information, the new name ErsA for the RNA was adopted.[3] Negatively regulates major porin oprD expression responsible for uptake of carbapenem antibiotics, by base pairing with oprD 5′UTR (leading to increased bacterial resistance to meropenem).[4] ErsA positively regulates amrZ mRNA and contributes to biofilm formation and motility.[5]
References
- ↑ "Comparative genomics reveals 104 candidate structured RNAs from bacteria, archaea, and their metagenomes". Genome Biology 11 (3): R31. March 2010. doi:10.1186/gb-2010-11-3-r31. PMID 20230605.
- ↑ 2.0 2.1 "Comparative profiling of Pseudomonas aeruginosa strains reveals differential expression of novel unique and conserved small RNAs". PLOS ONE 7 (5): e36553. May 2012. doi:10.1371/journal.pone.0036553. PMID 22590564. Bibcode: 2012PLoSO...736553F.
- ↑ 3.0 3.1 "Post-transcriptional regulation of the virulence-associated enzyme AlgC by the σ(22) -dependent small RNA ErsA of Pseudomonas aeruginosa". Environmental Microbiology 17 (1): 199–214. January 2015. doi:10.1111/1462-2920.12590. PMID 25186153.
- ↑ "Probing the sRNA regulatory landscape of P. aeruginosa: post-transcriptional control of determinants of pathogenicity and antibiotic susceptibility". Molecular Microbiology 106 (6): 919–937. December 2017. doi:10.1111/mmi.13857. PMID 28976035.
- ↑ "Pseudomonas aeruginosa Contributes to Biofilm Development and Motility through Post-transcriptional Modulation of AmrZ". Frontiers in Microbiology 9: 238. 2018. doi:10.3389/fmicb.2018.00238. PMID 29497413.
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