Biology:Phosphoenolpyruvate carboxykinase (diphosphate)
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Short description: Enzyme
| Phosphoenolpyruvate carboxykinase (diphosphate) | |||||||||
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 Phosphoenolpyruvate carboxykinase (pyrophosphate) homodimer, Actinomyces israelii | |||||||||
| Identifiers | |||||||||
| EC number | 4.1.1.38 | ||||||||
| CAS number | 2598306 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Phosphoenolpyruvate carboxykinase (diphosphate) (EC 4.1.1.38) is an enzyme with systematic name diphosphate:oxaloacetate carboxy-lyase (transphosphorylating; phosphoenolpyruvate-forming).[1] This enzyme catalyses the following chemical reaction
- diphosphate + oxaloacetate [math]\displaystyle{ \rightleftharpoons }[/math] phosphate + phosphoenolpyruvate + CO2
This enzyme also catalyses the reaction:
- phosphoenolpyruvate + GTP + CO2 [math]\displaystyle{ \rightleftharpoons }[/math] pyruvate + GDP.
It is transcriptionally upregulated in the liver by glucagon.
See also
References
External links
- Phosphoenolpyruvate+carboxykinase+(diphosphate) at the US National Library of Medicine Medical Subject Headings (MeSH)
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