Biology:Small Cajal body specific RNA 24

From HandWiki
Revision as of 14:58, 21 August 2021 by imported>Unex (over-write)
(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Small Cajal body specific RNA 24
RF00422.jpg
Predicted secondary structure and sequence conservation of SCARNA24
Identifiers
SymbolSCARNA24
Alt. SymbolssnoACA12
RfamRF00422
Other data
RNA typeGene; snRNA; snoRNA; scaRNA
Domain(s)Eukaryota
GO0006396 0015030 0005730
SO0000275
PDB structuresPDBe

Small Cajal body specific RNA 24 (also known as scaRNA24 or ACA12) is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation (isomerisation of uridine to pseudouridine) of U6 spliceosomal RNA.

scaRNAs are a specific class of small nucleolar RNAs that localise to the Cajal bodies and guide the modification of RNA polymerase II transcribed spliceosomal RNAs U1, U2, U4, U5 and U12.[1]

ACA12 belongs to the H/ACA box class of guide RNAs as it has the predicted hairpin-hinge-hairpin-tail structure, the conserved H/ACA-box motifs and is found associated with GAR1 protein.[2] ACA12 is predicted to guide the pseudouridylation of residue U40 of the spliceosomal U6 snRNA.[2][3]

References

External links