Biology:15-oxoprostaglandin 13-oxidase
| 15-oxoprostaglandin 13-oxidase | |||||||||
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| Identifiers | |||||||||
| EC number | 1.3.1.48 | ||||||||
| CAS number | 57406-74-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, 15-oxoprostaglandin 13-oxidase (EC 1.3.1.48) is an enzyme that catalyzes the chemical reaction
- REDIRECT Template:Chemical reaction
The two substrates of this enzyme are 15-oxodihydroprostaglandin E1 and oxidised nicotinamide adenine dinucleotide (NAD+). Its products are 15-oxoprostaglandin E1, reduced NADH, and a proton. The enzyme can also use nicotinamide adenine dinucleotide phosphate as an alternative cofactor.[1][2][3]
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (5Z)-(15S)-11alpha-hydroxy-9,15-dioxoprostanoate:NAD(P)+ Delta13-oxidoreductase. Other names in common use include 15-oxo-Delta13-prostaglandin reductase, Delta13-15-ketoprostaglandin reductase, 15-ketoprostaglandin Delta13-reductase, prostaglandin Delta13-reductase, prostaglandin 13-reductase, and 15-ketoprostaglandin Delta13-reductase.
Structural studies
As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1V3T, 1V3U, 1V3V, and 2DM6.
References
- ↑ Enzyme 1.3.1.48 at KEGG Pathway Database.
- ↑ "Purification and assay of 15-ketoprostaglandin Δ13-reductase from bovine lung". Prostaglandins and Arachidonate Metabolites. Methods in Enzymology. 86. 1982. pp. 156–63. doi:10.1016/0076-6879(82)86186-7. ISBN 978-0-12-181986-6.
- ↑ "Isolation and properties of a 15-ketoprostaglandin Δ13-reductase from human placenta". Prostaglandins and Arachidonate Metabolites. Methods in Enzymology. 86. 1982. pp. 163–7. doi:10.1016/0076-6879(82)86187-9. ISBN 978-0-12-181986-6.
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