Biology:2-methylisocitrate dehydratase
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Short description: Class of enzymes
| 2-methylisocitrate dehydratase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 4.2.1.99 | ||||||||
| CAS number | 170780-51-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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The enzyme 2-methylisocitrate dehydratase (EC 4.2.1.99) catalyzes the chemical reaction
- (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate [math]\displaystyle{ \rightleftharpoons }[/math] (Z)-but-2-ene-1,2,3-tricarboxylate + H2O
This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate hydro-lyase [(Z)-but-2-ene-1,2,3-tricarboxylate-forming]. This enzyme is also called (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate hydro-lyase. This enzyme participates in propanoate metabolism.
References
- "Isolation of 2-methylisocitrate dehydratase, a new enzyme serving in the methylcitric acid cycle for propionate metabolism, from Yarrowia lipolytica". Biosci. Biotechnol. Biochem. 59 (10): 1825–1828. 1995. doi:10.1271/bbb.59.1825.
- "Characteristics of 2-methylisocitrate dehydratase, isolated from Yarrowia lipolytica, in comparison to aconitase". Biosci. Biotechnol. Biochem. 59 (11): 2013–2017. 1995. doi:10.1271/bbb.59.2013.
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