Biology:23S rRNA pseudouridine2604 synthase
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Short description: Class of enzymes
| 23S rRNA pseudouridine2604 synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 5.4.99.21 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
23S rRNA pseudouridine2604 synthase (EC 5.4.99.21, RluF, YjbC) is an enzyme with systematic name 23S rRNA-uridine2604 uracil mutase.[1][2][3] This enzyme catalyses the following chemical reaction
- 23S rRNA uridine2604 [math]\displaystyle{ \rightleftharpoons }[/math] 23S rRNA pseudouridine2604
The enzyme can, to a small extent, also react with uridine2605.
References
- ↑ "Identification and site of action of the remaining four putative pseudouridine synthases in Escherichia coli". RNA 7 (11): 1603–15. November 2001. PMID 11720289.
- ↑ "Crystal structure of an RluF-RNA complex: a base-pair rearrangement is the key to selectivity of RluF for U2604 of the ribosome". Journal of Molecular Biology 388 (4): 785–800. May 2009. doi:10.1016/j.jmb.2009.03.029. PMID 19298824.
- ↑ "Domain organization and crystal structure of the catalytic domain of E.coli RluF, a pseudouridine synthase that acts on 23S rRNA". Journal of Molecular Biology 359 (4): 998–1009. June 2006. doi:10.1016/j.jmb.2006.04.019. PMID 16712869.
External links
- 23S+rRNA+pseudouridine2604+synthase at the US National Library of Medicine Medical Subject Headings (MeSH)
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