Biology:3-hydroxydecanoyl-(acyl-carrier-protein) dehydratase
From HandWiki
Short description: Class of enzymes
| 3-hydroxydecanoyl-(acyl-carrier-protein) dehydratase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 4.2.1.60 | ||||||||
| CAS number | 9030-79-9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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3-hydroxydecanoyl-(acyl-carrier-protein) dehydratase (EC 4.2.1.60, D-3-hydroxydecanoyl-[acyl-carrier protein] dehydratase, 3-hydroxydecanoyl-acyl carrier protein dehydrase, 3-hydroxydecanoyl-acyl carrier protein dehydratase, β-hydroxydecanoyl thioester dehydrase, β-hydroxydecanoate dehydrase, beta-hydroxydecanoyl thiol ester dehydrase, FabA, β-hydroxyacyl-acyl carrier protein dehydratase, HDDase, β-hydroxyacyl-ACP dehydrase, (3R)-3-hydroxydecanoyl-[acyl-carrier-protein] hydro-lyase) is an enzyme with systematic name (3R)-3-hydroxydecanoyl-(acyl-carrier protein) hydro-lyase.[1][2][3][4][5][6][7] This enzyme catalyses the following chemical reaction
- (1) a (3R)-3-hydroxydecanoyl-[acyl-carrier protein] [math]\displaystyle{ \rightleftharpoons }[/math] a trans-dec-2-enoyl-[acyl-carrier protein] + H2O
- (2) a (3R)-3-hydroxydecanoyl-[acyl-carrier protein] [math]\displaystyle{ \rightleftharpoons }[/math] a cis-dec-3-enoyl-[acyl-carrier protein] + H2O
This enzyme is specific for C10 chain length.
References
- ↑ "Beta-hydroxydecanoyl thioester dehydrase. I. Purification and properties". The Journal of Biological Chemistry 242 (19): 4418–31. October 1967. PMID 4863739.
- ↑ "Beta-hydroxydecanoyl thioester dehydrase. II. Mode of action". The Journal of Biological Chemistry 242 (19): 4432–40. October 1967. PMID 4863740.
- ↑ "Crystallization and preliminary X-ray analysis of beta-hydroxydecanoyl thiol ester dehydrase from Escherichia coli". The Journal of Biological Chemistry 265 (9): 5110–2. March 1990. PMID 2180957.
- ↑ "Regulation of fatty acid biosynthesis in Escherichia coli". Microbiological Reviews 57 (3): 522–42. September 1993. PMID 8246839.
- ↑ "Enzymatic synthesis of monounsaturated fatty acids". Acc. Chem. Res. 2: 193–202. 1969. doi:10.1021/ar50019a001.
- ↑ "Functional replacement of the FabA and FabB proteins of Escherichia coli fatty acid synthesis by Enterococcus faecalis FabZ and FabF homologues". The Journal of Biological Chemistry 279 (33): 34489–95. August 2004. doi:10.1074/jbc.M403874200. PMID 15194690.
- ↑ Neidhardt, F.C., ed (1996). "Biosynthesis of membrane lipids". Escherichia coli and Salmonella: Cellular and Molecular Biology. 1 (2nd ed.). Washington, DC: ASM Press. pp. 612–636.
External links
- 3-hydroxydecanoyl-(acyl-carrier-protein)+dehydratase at the US National Library of Medicine Medical Subject Headings (MeSH)
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