Biology:4-hydroxy-tetrahydrodipicolinate reductase

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Short description: InterPro Family
4-hydroxy-tetrahydrodipicolinate reductase
5ees.jpg
Dihydrodipicolinate reductase tetramer, Corynebacterium glutamicum
Identifiers
EC number1.17.1.8
CAS number9055-46-3
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a 4-hydroxy-tetrahydrodipicolinate reductase (EC 1.17.1.8) is an enzyme that catalyzes the chemical reaction

(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O [math]\displaystyle{ \rightleftharpoons }[/math] (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+

The 3 substrates of this enzyme are (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate, NAD+ or NADP+, and H2O, whereas its 3 products are (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate, NADH or NADPH, and H+.

This enzyme participates in lysine biosynthesis.

Nomenclature

This enzyme belongs to the family of oxidoreductases, specifically those acting on CH or CH2 groups with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate:NAD(P)+ 4-oxidoreductase. Other names in common use include:

  • dihydrodipicolinate reductase,
  • dihydrodipicolinic acid reductase, and
  • 2,3,4,5-tetrahydrodipicolinate:NAD(P)+ oxidoreductase.

References

Further reading

  • "The reduction step in diaminopimelic acid biosynthesis". The Journal of Biological Chemistry 240 (12): 4717–22. Dec 1965. doi:10.1016/S0021-9258(18)97014-6. PMID 4378965. 
  • "Dihydrodipicolinic acid reductase (Escherichia coli)". Methods Enzymol. 17B: 134–139. 1971. doi:10.1016/0076-6879(71)17030-9. 
  • "NMR studies uncover alternate substrates for dihydrodipicolinate synthase and suggest that dihydrodipicolinate reductase is also a dehydratase". Journal of Medicinal Chemistry 53 (12): 4808–12. Jun 2010. doi:10.1021/jm100349s. PMID 20503968.